PMID: 8458030Jan 1, 1993Paper

Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury

Cardiovascular Research
K M Mullane

Abstract

Acadesine is the prototype of a new class of therapeutic compounds termed adenosine regulating agents. Acadesine is pharmacologically silent in normal circumstances, but its activity becomes operative during situations of net ATP catabolism, when it increases local adenosine levels. Thus acadesine is able to harness the beneficial effects of this protective autacoid without the limiting side effects associated with using adenosine itself or an adenosine mimetic or transport inhibitor. The demonstrated efficacy of acadesine in various models of myocardial ischaemia and the preliminary clinical results 48 indicate that acadesine and other ARAs could represent important new additions to the cardiologist's armamentarium to combat myocardial ischaemia and its sequelae.

Citations

Sep 20, 2006·Pflügers Archiv : European journal of physiology·Terence R MoopanarDavid G Allen
Dec 18, 2012·American Journal of Physiology. Cell Physiology·Edwin K JacksonDelbert G Gillespie
Sep 17, 2008·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Lenka BartosikovaMartin Pavlik
Nov 28, 2013·Pharmacology & Therapeutics·Offir ErtrachtOfer Binah
Mar 1, 2002·Expert Review of Neurotherapeutics·John W Phillis
Jan 19, 2016·Oncogenesis·F BostS Clavel
Jul 21, 2010·The American Journal of Cardiology·Aslan T Turer, Joseph A Hill
Jul 1, 1994·The Annals of Thoracic Surgery·F W SellkeR G Johnson
Mar 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·J P MathewB R Smith
Mar 13, 2014·Drug Discovery Today·Luca AntonioliGyörgy Haskó
Jul 27, 2011·Biochemical Pharmacology·Rosanna Di PaolaSalvatore Cuzzocrea
Jan 29, 2000·European Journal of Clinical Investigation·F PaganelliR Guieu
Oct 12, 2000·Acta Anaesthesiologica Scandinavica·H T Sommerschild, K A Kirkebøen
Apr 13, 1999·Critical Care Medicine·S M MeltonK G Proctor
Jul 12, 2003·The Journal of Trauma·Michael E KellyKenneth G Proctor
Nov 22, 2000·The Journal of Trauma·K A DavisK G Proctor
Jan 12, 2001·Critical Care Medicine·D N Ragsdale, K G Proctor
Mar 3, 2007·Circulation Research·Michael AradJ G Seidman
May 2, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jagdip S JaswalAlexander S Clanachan
Feb 28, 2001·Anesthesia and Analgesia·I Matot, O Jurim
Mar 2, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Theresa PangMorris Karmazyn
Nov 19, 2002·The Journal of Trauma·Matthew J Fabian, Kenneth G Proctor
Feb 9, 2020·Cardiovascular Drugs and Therapy·Kerstin N Timm, Damian J Tyler
Sep 11, 2019·Journal of Molecular and Cellular Cardiology·Yan DongJie Wang
Nov 9, 2020·Biochemical Pharmacology·Detlev Boison, Michael F Jarvis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.