Acanthamoeba and the blood-brain barrier: the breakthrough

Journal of Medical Microbiology
Naveed Ahmed Khan

Abstract

Acanthamoeba granulomatous encephalitis is a rare disease that almost always proves fatal. Death occurs mainly due to neurological complications; however, the pathogenesis and pathophysiology associated with this disease remain incompletely understood. Haematogenous spread is a key step in the development of Acanthamoeba encephalitis, but it is not clear how circulating amoebae breakthrough the blood-brain barrier to gain entry into the central nervous system to produce the disease. This review of the literature describes the parasite factors and immune-mediated mechanisms involved in the blood-brain barrier dysfunction leading to neuropathogenesis.

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Citations

Jul 8, 2010·Infection and Immunity·Jenica L HarrisonGuy A Cabral
Jun 9, 2012·Parasites & Vectors·Ruqaiyyah SiddiquiNaveed Ahmed Khan
Mar 4, 2015·Open Forum Infectious Diseases·Susanna K TanRichard Ha
Apr 1, 2011·Journal of Pharmaceutical Sciences·Elisabetta GaviniAlessandro Dalpiaz
Apr 24, 2012·Pathologie-biologie·H TrabelsiA Ayadi
Jul 28, 2009·Acta Tropica·Gabriela A FerreiraSilvia C Alfieri
Aug 25, 2009·Experimental Parasitology·Bruno da Rocha-AzevedoFrancine Marciano-Cabral
Jul 8, 2009·International Journal for Parasitology·Naveed Ahmed Khan, Ruqaiyyah Siddiqui
Dec 22, 2012·Microbiology·Mineko ShibayamaJesús Serrano-Luna
Mar 27, 2010·FEMS Microbiology Reviews·Hany M Elsheikha, Naveed Ahmed Khan
Nov 19, 2011·FEMS Immunology and Medical Microbiology·Elena BencurovaMangesh Bhide
Dec 26, 2012·Diagnostic Microbiology and Infectious Disease·Ahmed M AlkhunaiziAli H Boukhamseen
Sep 27, 2012·Experimental Parasitology·Yousuf AqeelNaveed Ahmed Khan
Sep 17, 2016·Asian Pacific Journal of Tropical Medicine·Tooba MahboobChristophe Wiart
Jan 10, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Max N BrondfieldJennifer M Babik
Feb 6, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ram V NampoothiriSubhash Varma
Mar 8, 2020·Parasites & Vectors·Karolina KotNatalia Łanocha-Arendarczyk
Jul 28, 2019·Journal of Cellular Physiology·Mahdi HatamipourAmirhossein Sahebkar
Apr 23, 2020·Journal of Family Medicine and Primary Care·Sohini DasRamya Iyadurai
May 18, 2021·Journal of Tropical Pediatrics·Sevliya Öcal DemirBegümhan Baysal
Aug 31, 2021·The Lancet Infectious Diseases·Gregory L DamhorstJennifer R Cope

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