Acanthamoeba infection in a patient with chronic graft-versus-host disease occurring during treatment with voriconazole

Transplant Infectious Disease : an Official Journal of the Transplantation Society
D R KaulG A Yanik

Abstract

We report a case of disseminated infection with Acanthamoeba in a patient with graft-versus-host disease after hematopoietic stem cell transplant (HSCT) for acute lymphocytic leukemia. The infection involved the brain, skin, and lungs and occurred despite treatment with voriconazole for mold prophylaxis, and did not respond to treatment with multiple other agents reported to have activity against Acanthamoeba. To our knowledge, infection with Acanthamoeba has been reported in 4 other patients after HSCT or bone marrow transplant, and our case is the first to be diagnosed ante-mortem.

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Citations

Oct 28, 2009·Current Infectious Disease Reports·Joshua Wolf, Monica A Slavin
Feb 23, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G AkpekM R Baer
Jul 8, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A L YoungM E Grossman
Nov 6, 2015·Surgical Neurology International·Ninh DoanVijay Johnson
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Sep 19, 2017·Pediatric Transplantation·Scott L CovenRajinder P S Bajwa
Sep 8, 2016·Antimicrobial Agents and Chemotherapy·Ruqaiyyah SiddiquiNaveed Ahmed Khan
May 11, 2018·Current Medicinal Chemistry·Naveed Ahmed KhanRuqaiyyah Siddiqui
Sep 15, 2016·The Pediatric Infectious Disease Journal·Antonio JuanCristina Díaz de Heredia
May 30, 2009·Scandinavian Journal of Infectious Diseases·Hadi AbdGunnar Sandström
Oct 13, 2020·American Journal of Ophthalmology·Praneetha ThulasiElmer Y Tu
Jan 31, 2021·International Journal of Molecular Sciences·Karolina KotDanuta Kosik-Bogacka
Jun 17, 2021·Journal of Clinical Microbiology·Aaron Kofman, Jeannette Guarner
Nov 6, 2009·Current Opinion in Supportive and Palliative Care

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