PMID: 9164992May 1, 1997Paper

Acarbose enhances human colonic butyrate production

The Journal of Nutrition
G A WeaverM J Wolin

Abstract

Earlier studies suggest that butyrate has colonic differentiating and nutritional effects and that acarbose increases butyrate production. To determine the effects of acarbose on colonic fermentation, subjects were given 50-200 mg acarbose or placebo (cornstarch), three times per day, with meals in a double-blind crossover study. Fecal concentrations of starch and starch-fermenting bacteria were measured and fecal fermentation products determined after incubation of fecal suspensions with and without added substrate for 6 and 24 h. Substrate additions were cornstarch, cornstarch plus acarbose and potato starch. Dietary starch consumption was similar during acarbose and placebo treatment periods, but fecal starch concentrations were found to be significantly greater with acarbose treatment. Ratios of starch-fermenting to total anaerobic bacteria were also significantly greater with acarbose treatment. Butyrate in feces, measured either as concentration or as percentage of total short-chain fatty acids, was significantly greater with acarbose treatment than with placebo treatment. Butyrate ranged from 22.3 to 27.5 mol/100 mol for the 50-200 mg, three times per day doses of acarbose compared with 18.3-19.3 mol/100 mol for the comp...Continue Reading

References

Mar 1, 1992·The American Journal of Clinical Nutrition·H KashtanW R Bruce
Aug 1, 1988·Scandinavian Journal of Gastroenterology·W ScheppachH Kasper
Jan 14, 1993·The New England Journal of Medicine·S P PerrineN F Olivieri
Feb 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·T M WoleverM H Tan

❮ Previous
Next ❯

Citations

Jul 22, 2011·American Journal of Physiology. Cell Physiology·Pedro GonçalvesFátima Martel
Mar 27, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·R E Wachters-HagedoornR J Vonk
Dec 31, 2016·Nutrition and Healthy Aging·Rachel A BrewerDaniel L Smith
Jan 29, 2017·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Xiuying ZhangLinong Ji
Jun 28, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Victoria K GibbsDaniel L Smith
Dec 26, 2018·Critical Reviews in Food Science and Nutrition·Xiaodan FuQing Kong
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J H Cummings
Apr 25, 2006·Journal of Clinical Gastroenterology·Julia M W WongDavid J A Jenkins
Oct 13, 2010·Nutrition Research Reviews·P GuilloteauF Van Immerseel
Mar 12, 2003·The British Journal of Nutrition·Asa M HenningssonInger M E Björck
Mar 12, 2008·The British Journal of Nutrition·Wokadala Cuthbert ObiroBo Jiang
Aug 8, 2015·Biology of Sex Differences·Padmaja ShastriJulia M Green-Johnson
Feb 9, 2017·International Journal of Molecular Sciences·Elisa BorghiAglaia Vignoli
Jan 4, 2018·Annual Review of Food Science and Technology·Katri Korpela
Oct 5, 2017·Genes·Sophie A Montandon, François R Jornayvaz
Nov 2, 2007·Alimentary Pharmacology & Therapeutics·H M HamerR-J Brummer
Jul 31, 2018·Journal of Animal Science·Sofia SchaufCarlos Castrillo
Feb 20, 2019·Diseases·Nima H JazaniNosratola D Vaziri
Sep 11, 2020·International Journal of Microbiology·Ingrid S Surono, Koen Venema
Oct 19, 2019·Trends in Microbiology·Filipe M CerqueiraNicole M Koropatkin
Jul 31, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Reza Rastmanesh
Aug 30, 2007·BMC Physiology·Jean-Louis GallisMarie-Christine Beauvieux

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.