Accelerated atherosclerosis in patients with SLE--mechanisms and management.

Nature Reviews. Rheumatology
Brian J SkaggsMaureen McMahon

Abstract

Rapid-onset cardiovascular disease (CVD) is a major concern for many patients with systemic lupus erythematosus (SLE). Cardiovascular events occur more frequently and with earlier onset in patients with SLE compared with healthy individuals. Traditional risk factors, such as altered lipid levels, aging and smoking, do not fully explain this increased risk of CVD, strongly suggesting that autoimmunity contributes to accelerated atherosclerosis. Altered immune system function is recognized as the primary contributor to both the initiation and progression of atherosclerosis. Multiple manifestations of autoimmunity, including changes in cytokine levels and innate immune responses, autoantibodies, adipokines, dysfunctional lipids, and oxidative stress, could heighten atherosclerotic risk. In addition, multiple SLE therapeutics seem to affect the development and progression of atherosclerosis both positively and negatively. SLE-specific cardiovascular risk factors are beginning to be discovered by several groups, and development of a comprehensive, clinically feasible biomarker panel could be invaluable for identification and treatment of patients at risk of developing accelerated atherosclerosis. Here, we discuss the epidemiology of...Continue Reading

References

Feb 1, 1976·The American Journal of Medicine·M B UrowitzM A Ogryzlo
Nov 1, 1992·The American Journal of Medicine·M PetriM C Hochberg
May 1, 1991·Hypertension·J D Coffman
Apr 1, 1996·Nature Medicine·K S McCully
May 1, 1996·The Journal of Clinical Investigation·K UyemuraR L Modlin
Jul 4, 1997·The Journal of Biological Chemistry·G R UpchurchJ Loscalzo
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R WuA K Lefvert
Apr 17, 2001·Hypertension·F SelzerS Manzi
Oct 17, 2001·Circulation·E SvenungssonJ Frostegård
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·G K Hansson
Mar 20, 2002·The Journal of Clinical Investigation·Giuseppina CaligiuriGöran K Hansson
Aug 13, 2002·Rheumatology International·Araceli Garcia-GonzalezJorge I Gamez-Nava
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Amy S MajorMacRae F Linton
Nov 26, 2002·Clinical Rheumatology·T M K RefaiM H Al-Salem
Dec 20, 2002·Nature·Peter Libby
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Aug 19, 2003·Annals of the Rheumatic Diseases·K MangerB Manger
Dec 19, 2003·The New England Journal of Medicine·Mary J RomanJane E Salmon
Dec 19, 2003·The New England Journal of Medicine·Yu AsanumaC Michael Stein
Apr 14, 2004·Seminars in Arthritis and Rheumatism·Jessica E NordMichael H Weisman
May 25, 2004·Annals of the Rheumatic Diseases·P R J AmesV Brancaccio
Jul 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P L MeroniM O Borghi
Dec 14, 2004·Arthritis and Rheumatism·Sergio M A TolozaUNKNOWN LUMINA Study Group
Jun 18, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Mohamad NavabAlan M Fogelman
Aug 16, 2005·The American Journal of Cardiology·Neil J StoneSara Rosenbaum
Oct 7, 2005·Arthritis and Rheumatism·Karen H CostenbaderMatthew H Liang
May 2, 2006·Arthritis Research & Therapy·Michelle JacksonPaul E C Brenchley

❮ Previous
Next ❯

Citations

Aug 12, 2014·Seminars in Immunopathology·Tony N Marion, Arnold E Postlethwaite
Jun 4, 2014·Current Atherosclerosis Reports·Liang-Yin KeChu-Huang Chen
Oct 9, 2013·Nature Reviews. Rheumatology·Andras Perl
Jan 1, 2016·Leukemia Research·Anders Lindholm Sørensen, Hans Carl Hasselbalch
Jan 5, 2016·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Mari KamiyaHitoshi Kohsaka
Dec 30, 2015·Seminars in Arthritis and Rheumatism·Konstantinos TseliosMurray B Urowitz
Jun 26, 2012·Immunological Reviews·Betty Diamond, Bruce T Volpe
Mar 20, 2013·Arthritis and Rheumatism·Josephine IsgroAlessandra B Pernis
Oct 30, 2014·Clinical and Experimental Immunology·E AmmiratiP G Camici
Apr 3, 2014·Arthritis Care & Research·José Mario SabioJuan Jiménez-Alonso
Dec 12, 2012·Clinical & Developmental Immunology·P C TeixeiraN Vuilleumier
May 13, 2014·Annals of Medicine·Andrew P Sage, Ziad Mallat
May 3, 2015·Current Atherosclerosis Reports·Monika Sanghavi, Martha Gulati
Oct 23, 2012·Atherosclerosis·Chiara Bolego
Feb 11, 2015·International Journal for Parasitology·Tamar R AprahamianIan R Rifkin
Sep 4, 2014·Frontiers in Immunology·Enrico AmmiratiPaolo G Camici
Sep 8, 2012·Autoimmune Diseases·Athina PyrpasopoulouSpyros Aslanidis
Sep 14, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Zejun ZhouWei Jiang
May 5, 2017·Expert Review of Clinical Immunology·Luis Alonso González, Graciela S Alarcón
Mar 5, 2013·Neurological Research·Christos LazaridisMarek Czosnyka
Apr 15, 2017·Critical Care Medicine·Claire Dahyot-FizelierOlivier Mimoz
Jan 3, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gali UmschweifEsther Shohami

❮ Previous
Next ❯

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