Accelerated Bone Loss in Older Men: Effects on Bone Microarchitecture and Strength

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Jane A CauleyOsteoporotic Fractures in Men (MrOS) Research Group

Abstract

Accelerated bone loss (ABL) shown on routine dual-energy X-ray absorptiometry (DXA) may be accompanied by microarchitectural changes, increased cortical porosity, and lower bone strength. To test this hypothesis, we performed a cross-sectional study and used high-resolution peripheral quantitative computed tomography (HR-pQCT) scans (Scanco Medical AG, Brüttisellen, Switzerland) to measure estimated bone strength and microarchitecture in the distal radius and distal and diaphyseal tibia. We studied 1628 men who attended the year 14 exam of the Osteoporotic Fractures in Men (MrOS) study. We retrospectively characterized areal bone mineral density (aBMD) change from the year 7 to year 14 exam in three categories: "accelerated" loss, ≥10% loss at either the total hip or femoral neck (n = 299, 18.4%); "expected" loss, <10% (n = 1061, 65.2%), and "maintained" BMD, ≥0% (n = 268, 16.5%). The ABL cut-off was a safety alert established for MrOS. We used regression models to calculate adjusted mean HR-pQCT parameters in men with ABL, expected loss, or maintained BMD. Men who experienced ABL were older and had a lower body mass index and aBMD and experienced greater weight loss compared with other men. Total volumetric BMD and trabecular ...Continue Reading

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Citations

Feb 5, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Erin Mr BigelowKarl J Jepsen
May 28, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D E WhittierM L Bouxsein
Apr 7, 2021·Aging Clinical and Experimental Research·Jean-Marc Kaufman
Sep 17, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Eric OrwollUNKNOWN Osteoporotic Fractures in Men Study (MrOS) Research Group
Jul 1, 2019·Gerontology·Maria PapageorgiouPeter Pietschmann

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