Accelerated Bone Regeneration by Nitrogen-Doped Carbon Dots Functionalized with Hydroxyapatite Nanoparticles

ACS Applied Materials & Interfaces
Deepak Kumar KhajuriaDavid Karasik

Abstract

We investigated the osteogenic potential of nitrogen-doped carbon dots (NCDs) conjugated with hydroxyapatite (HA) nanoparticles on the MC3T3-E1 osteoblast cell functions and in a zebrafish (ZF) jawbone regeneration (JBR) model. The NCDs-HA nanoparticles were fabricated by a hydrothermal cum co-precipitation technique. The surface structures of NCDs-HA nanoparticles were characterized by X-ray diffraction; Fourier transform infrared (FTIR), UV-vis, and laser fluorescence spectroscopies; and scanning electron microscopy, transmission electron microscopy (TEM), energy-dispersive spectrometry (EDS), and NMR analyses. The TEM data confirmed that the NCDs are well conjugated on the HA nanoparticle surfaces. The fluorescent spectroscopy results indicated that the NCDs-HA exhibited promising luminescent emission in vitro. Finally, we validated the chemical structure of NCDs-HA nanoparticles on the basis of FTIR, EDS, and 31P NMR analysis and observed that NCDs are bound with HA by electrostatic interaction and H-bonding. Cell proliferation assay, alkaline phosphatase, and Alizarin red staining were used to confirm the effect of NCDs-HA nanoparticles on MC3T3-E1 osteoblast proliferation, differentiation, and mineralization, respectively...Continue Reading

References

Nov 27, 2009·Nature·Nathaniel Huebsch, David J Mooney
Mar 29, 2014·Journal of Food and Drug Analysis·Zhen FanParesh C Ray
Dec 3, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Deepak Kumar KhajuriaDebiprosad Roy Mahapatra
Mar 21, 2015·Experimental & Molecular Medicine·Jeong-Ha HwangKang-Yell Choi
Apr 7, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Baiyao XuGuanbin Song
Sep 20, 2015·Ultrasonics Sonochemistry·Vijay Bhooshan KumarAharon Gedanken
Nov 12, 2015·Bone Research·Tao GongYunfeng Lin
Dec 22, 2015·Scientific Reports·Jong Ho LeeDong-Wook Han
May 16, 2017·ACS Applied Materials & Interfaces·Deepak Kumar KhajuriaAharon Gedanken
May 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Vijay Bhooshan KumarAharon Gedanken
Dec 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hao ChenYu Tang

❮ Previous
Next ❯

Citations

Nov 19, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sergey V Dorozhkin
Jan 25, 2020·Advanced Healthcare Materials·Zhili PengRoger M Leblanc
Jun 12, 2019·Biomedical Materials·Vijay Bhooshan KumarAharon Gedanken
Dec 6, 2019·Biomedical Materials·Giulia MolinoChiara Vitale-Brovarone
May 10, 2020·Journal of Fish Biology·Deepak Kumar Khajuria, David Karasik
Oct 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiyu LiWei Li
Nov 3, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Roya KoshaniTheo G M van de Ven
Mar 12, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Poushali DasAharon Gedanken
Mar 28, 2020·ACS Applied Materials & Interfaces·Le YuMei Wei
Sep 10, 2021·ACS Biomaterials Science & Engineering·Shrinath BhatMahaveer D Kurkuri
Sep 30, 2021·ACS Biomaterials Science & Engineering·Haoyang LiuWei Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.