PMID: 3761133May 1, 1986Paper

Accelerated clearance of intravenously administered theophylline and phenobarbital by oral doses of activated charcoal in rats. A possibility of the intestinal dialysis

Journal of Pharmacobio-dynamics
K Arimori, M Nakano

Abstract

The effect of oral administration of activated charcoal on the clearance of theophylline and phenobarbital following their intravenous administration was studied in rats. Oral administration of multiple doses of activated charcoal significantly decreased the serum half-life and AUC (area under the curve) and increased the total body clearance of both theophylline and phenobarbital as compared with their respective controls. The volume of distribution was not significantly different between treatments. A single dose of activated charcoal showed only a slight enhancement of clearance of theophylline. Accelerated clearance of both drugs by oral activated charcoal was rationalized in terms of adsorption of exsorbed drugs and inhibition of their reabsorption by activated charcoal in the gastrointestinal tract.

Citations

Jun 9, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K WaltonA G Renwick
Dec 1, 1992·The Journal of Pharmacy and Pharmacology·K ArimoriM Nakano
Mar 1, 1990·The Journal of Pharmacy and Pharmacology·J D Huang
Sep 1, 2006·International Journal of Pharmaceutics·Kenta YamamotoYoshiharu Machida
Apr 2, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masahiro Nakano
Oct 14, 2011·International Journal of Emergency Medicine·Timothy E AlbertsonAndrew L Chan
Jun 10, 2005·Basic & Clinical Pharmacology & Toxicology·Sage W Wiener, Robert S Hoffman
Jan 1, 1995·Journal of Toxicology. Clinical Toxicology·S M Bradberry, J A Vale
Jun 21, 2019·Deutsches Ärzteblatt International·Tobias ZellnerFlorian Eyer
Aug 24, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lotte C G HoegbergSophie Gosselin

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