Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis

Cell Death and Differentiation
Theodore O GarnettPenelope J Duerksen-Hughes

Abstract

Viruses have developed sophisticated strategies to evade host defenses and facilitate the production and spread of progeny. In this study, we show that transfection of the human papillomavirus (HPV) 16 E6 oncogene into HCT116 cells provides protection from tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis. Additionally, we demonstrate that the protection provided by E6 is dose-dependent because higher levels of E6 provide greater protection. The mechanism underlying this protection involves a rapid reduction in the protein levels of both Fas-associated death domain (FADD) and procaspase 8, which results in suppression of the activation of caspases 8, 3 and 2. Interestingly, E6 does not interfere with the mitochondrial apoptotic pathway even though HCT116 cells have been classified as type II cells with regard to TRAIL signaling. These findings demonstrate that E6 has a more generalized effect on signaling by death ligands than was previously thought and support the notion that E6 can utilize p53-independent mechanisms to modulate cell survival.

References

Apr 4, 1997·Science·G PanV M Dixit
Aug 22, 1997·The Journal of Biological Chemistry·H LiJ Yuan
Mar 4, 1998·European Journal of Immunology·I JeremiasK M Debatin
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·S Gross-MesilatyA Ciechanover
Jan 9, 1999·Oncogene·M Thomas, L Banks
Apr 20, 1999·The Journal of Experimental Medicine·T S GriffithN A Fanger
Jul 20, 1999·The Journal of Clinical Investigation·A AshkenaziR H Schwall
Dec 14, 1999·Nature Structural Biology·J MongkolsapayaG R Screaton
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·A SkaletskayaV S Goldmacher
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P HubertP Delvenne
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
Dec 18, 2001·European Journal of Immunology·K SatoK Ogasawara
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Paola PisaniD Maxwell Parkin
Feb 8, 2002·The Journal of Biological Chemistry·Yin GuoEmad S Alnemri
Apr 6, 2002·The Journal of Biological Chemistry·Maria FilippovaPenelope J Duerksen-Hughes
Jun 18, 2002·The Journal of Biological Chemistry·John D RobertsonSten Orrenius
Oct 31, 2002·Nature Immunology·Chris A BenedictCarl F Ware
Oct 31, 2002·Neoplasia : an International Journal for Oncology Research·Nesrin Ozören, Wafik S El-Deiry
May 27, 2003·BioTechniques·Rosa A CarrascoBharvin K R Patel
Jun 6, 2003·Cytokine & Growth Factor Reviews·Alexandru Almasan, Avi Ashkenazi
Jun 6, 2003·Cytokine & Growth Factor Reviews·Chris A Benedict
Apr 10, 2004·The Journal of Biological Chemistry·Maria FilippovaPenelope J Duerksen-Hughes
Jun 3, 2004·The Journal of Biological Chemistry·Klaus W WagnerQuinn L Deveraux
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Michelle S Longworth, Laimonis A Laimins
Nov 19, 2004·Chembiochem : a European Journal of Chemical Biology·Karson S PuttPaul J Hergenrother

❮ Previous
Next ❯

Citations

Mar 15, 2011·Archives of Dermatological Research·Qiang ZhouHao Cheng
Dec 25, 2012·Archives of Gynecology and Obstetrics·Qiong CaiAiping Dian
Jul 25, 2006·Archives of Virology·T O Garnett, P J Duerksen-Hughes
Apr 14, 2007·Apoptosis : an International Journal on Programmed Cell Death·Theodore O GarnettPenelope Jayne Duerksen-Hughes
Apr 14, 2009·Apoptosis : an International Journal on Programmed Cell Death·Xiaoqin WangHuachen Wei
May 12, 2009·Journal of Biosciences·Niladri Ganguly, Suraj P Parihar
Jul 2, 2010·Nature Reviews. Cancer·Cary A Moody, Laimonis A Laimins
Jul 18, 2008·Journal of Virology·Sandy S TungteakkhunPenelope J Duerksen-Hughes
Oct 5, 2007·Journal of Virology·Sungyong WonShinji Makino
Jun 19, 2013·Cancer Cell International·Talha Abdul HalimFarrukh Zaman
Jun 8, 2013·Virology Journal·Alma Mariana Fuentes-GonzálezMarcela Lizano
Oct 25, 2014·Viruses·Abigail Morales-Sánchez, Ezequiel M Fuentes-Pananá
Nov 21, 2012·Microbial Pathogenesis·Chai Ling Pang, Françoise Thierry
Mar 18, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sabitha RamakrishnanGaneshan Mathan
Jan 6, 2012·Journal of Oncology·E Guzmán-OleaV Madrid-Marina
Dec 3, 2014·La Presse médicale·Dorien Van HedeNathalie Jacobs
Nov 20, 2014·International Journal of Cancer. Journal International Du Cancer·Amy HollowayAlan Storey
Feb 4, 2012·Bioorganic & Medicinal Chemistry Letters·Chung-Hsiang YuanJohn L Krstenansky
Dec 24, 2014·Biochimica Et Biophysica Acta·Cesira FoppoliM Perluigi
Apr 26, 2015·Virologica Sinica·Liyan Jin, Zhi-Xiang Xu
Jan 7, 2014·Biochimica Et Biophysica Acta·Antonio Carlos de FreitasMaria da Conceição Gomes Leitão
Dec 17, 2008·Virology·Heather L HowieDenise A Galloway
Oct 22, 2016·Apoptosis : an International Journal on Programmed Cell Death·Alfredo Lagunas-MartínezPatricio Gariglio
May 20, 2017·Cell Death and Differentiation·Patrick F Connolly, Howard O Fearnhead
Oct 28, 2017·Viruses·Xingchen ZhouXiaozhen Liang
Nov 14, 2018·International Journal of Cancer. Journal International Du Cancer·Olga RatajThomas Iftner
Jan 4, 2018·Oncotarget·Marie-Laure PlissonnierIsabelle Lascombe
Nov 7, 2019·International Journal of Molecular Sciences·Mitsuhiro NakamuraHiroshi Fujiwara
Aug 13, 2020·Cellular & Molecular Biology Letters·Shuangyang TangYimou Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis