Accelerated development of a Th-2 type factor in animals with and without an imbalance between help and suppression

Experientia
T Matsuzawa, B Cinader

Abstract

A helper factor can be detected in antigen-treated supernatants from spleen T and adherent cells of sensitized animals. This factor promotes an indirect hapten-specific plaque forming response of B cells, irrespective of the identity of the carrier, i.e. provides the Th-2 type of help. Factor production increases with age and occurs most rapidly in strains known to have an accelerated decrease of suppressor capacity. The reason for the inverse correlation between suppressor capacity and the Th-2 type of helper factor is discussed.

References

Jan 1, 1977·International Archives of Allergy and Applied Immunology·M Hosono, B Cinader
Jan 1, 1977·Immunological Communications·M HosonoJ R Ellerson
Oct 1, 1978·Cellular Immunology·B CinaderS Koh
Apr 1, 1974·Cellular Immunology·M Fujiwara, B Cinader
Nov 1, 1981·European Journal of Immunology·T Amagai, B Cinader
Jan 1, 1981·Immunological Communications·T Amagai, B Cinader
Sep 15, 1982·Experientia·T Matsuzawa, B Cinader
May 1, 1982·Cellular Immunology·T Matsuzawa, B Cinader
Aug 1, 1982·Journal of Immunogenetics·T Matsuzawa, B Cinader
Apr 1, 1980·European Journal of Immunology·K Nakano, B Cinader
Nov 1, 1981·The Journal of Experimental Medicine·D WofsyN Talal
Jan 1, 1980·Scandinavian Journal of Immunology·K Nakano, B Cinader

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