Accelerated enamel mineralization in Dspp mutant mice

Matrix Biology : Journal of the International Society for Matrix Biology
Kostas VerdelisElia Beniash

Abstract

Dentin sialophosphoprotein (DSPP) is one of the major non-collagenous proteins present in dentin, cementum and alveolar bone; it is also transiently expressed by ameloblasts. In humans many mutations have been found in DSPP and are associated with two autosomal-dominant genetic diseases - dentinogenesis imperfecta II (DGI-II) and dentin dysplasia (DD). Both disorders result in the development of hypomineralized and mechanically compromised teeth. The erupted mature molars of Dspp(-/-) mice have a severe hypomineralized dentin phenotype. Since dentin and enamel formations are interdependent, we decided to investigate the process of enamel onset mineralization in young Dspp(-/-) animals. We focused our analysis on the constantly erupting mouse incisor, to capture all of the stages of odontogenesis in one tooth, and the unerupted first molars. Using high-resolution microCT, we revealed that the onset of enamel matrix deposition occurs closer to the cervical loop and both secretion and maturation of enamel are accelerated in Dspp(-/-) incisors compared to the Dspp(+/-) control. Importantly, these differences did not translate into major phenotypic differences in mature enamel in terms of the structural organization, mineral density...Continue Reading

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Citations

Oct 21, 2016·Human Mutation·Fu XiongXiangmin Xu
Jun 8, 2019·Journal of Dental Research·T LiangY Lu
Oct 20, 2019·The Journal of Biological Chemistry·Xu YangElia Beniash
Jan 11, 2020·The Journal of Biological Chemistry·Nah-Young ShinHenry C Margolis
Nov 27, 2020·Frontiers in Physiology·Ce ShiQilin Liu
Nov 16, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ninna ShuhaibarMark Terasaki
Nov 4, 2020·International Journal of Molecular Sciences·Yam Prasad AryalJae-Young Kim
Mar 30, 2021·JBMR Plus·Michael B ChavezBrian L Foster

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