Accelerated endometrial maturation in the luteal phase of cycles utilizing controlled ovarian hyperstimulation: impact of gonadotropin-releasing hormone agonists versus antagonists

Fertility and Sterility
Peyman SaadatR J Paulson

Abstract

To evaluate the endometrium obtained during the luteal phase of controlled ovarian hyperstimulation (COH) cycles utilizing gonadotropin-releasing hormone (GnRH) antagonists, and to compare these findings with those obtained in cycles utilizing a GnRH agonist and with artificial cycles among recipients. Prospective evaluation of oocyte donors. University-based in vitro fertilization (IVF) center. Fifteen oocyte donors undergoing standard COH were enrolled in 1 of 3 COH groups, and 40 recipients of oocyte donation were used as a control group. Controlled ovarian hyperstimulation and endometrial biopsy. Histological dating of endometrial biopsies, serum estradiol (E(2)) and progesterone levels. On the day of oocyte retrieval, endometrial maturation was advanced by an average of 5.8 +/- 0.4 days in the antagonist group and 5.9 +/- 0.7 days in the agonist group. This advancement persisted on day 7 postoocyte retrieval. Serum progesterone levels were elevated before human chorionic gonadotropin (hCG) administration, but remained similar in both groups. Controlled ovarian hyperstimulation is associated with elevated progesterone levels in the late follicular phase and accelerated endometrial maturation in the subsequent luteal phase. ...Continue Reading

References

Aug 1, 1995·Journal of Assisted Reproduction and Genetics·T J Gelety, R P Buyalos
Jun 17, 1997·Annals of the New York Academy of Sciences·G Nikas, A Psychoyos
Feb 13, 2001·Fertility and Sterility·M FlukerUNKNOWN North American Ganirelix Study Group

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Citations

Dec 1, 2007·Journal of Assisted Reproduction and Genetics·Porntip SirayapiwatSomchai Niruthisard
Mar 21, 2009·Journal of Assisted Reproduction and Genetics·Mustafa BahceciBora Cengiz
Oct 16, 2008·Reproductive Biomedicine Online·M H van der GaastN S Macklon
Jan 1, 2008·Journal of Human Reproductive Sciences·Kamath MsGeorge K
Dec 15, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Berfu DemirLeyla Mollamahmutoglu
Nov 29, 2011·Reproductive Biomedicine Online·Delphine HaouziSamir Hamamah
Jul 11, 2009·Gynécologie, obstétrique & fertilité·C SiferC Poncelet
Feb 12, 2005·Fertility and Sterility·Bruce A Lessey, Ryszard J Chetkowski
Nov 10, 2004·Fertility and Sterility·Efstratios KolibianakisPaul Devroey
Nov 23, 2006·Fertility and Sterility·Neal G Mahutte, Aydin Arici
Sep 9, 2015·Journal of Assisted Reproduction and Genetics·Heather BurksRichard Paulson
Jul 13, 2006·Human Reproduction Update·Thomas StrowitzkiM von Wolff
May 25, 2006·American Journal of Physiology. Endocrinology and Metabolism·Rebecca L KelleyLisa J Edwards
Feb 14, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Cindrilla Chumduri, Margherita Y Turco
Feb 10, 2020·Trends in Endocrinology and Metabolism : TEM·Paola ViganòEdgardo Somigliana

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