Accelerated epidermal regeneration and improved dermal reconstruction achieved by polyethersulfone nanofibers

Tissue Engineering. Part a
Farshad BabaeijandaghiMasoud Soleimani

Abstract

In this study, thick polyethersulfone (PES) nanofibrous scaffolds were prepared by fine tuning of electrospinning parameters and was evaluated for wound dressing applications. Scanning electron microscopy and Brunauer-Emmett-Teller methods were used for PES nanofibers characterization. The interaction between fibroblasts and nanofibers was studied in vitro. Further, a mouse model was used to evaluate the effectiveness of the PES scaffold in wound healing. Vaseline gauze dressing and a conventional gas permeable bandage were used as a control. The wound repair process was evaluated by histological examination and immunohistochemistry staining using antibodies to cytokeratin 10 (CK10), proliferating cell nuclear antigen (PCNA), and alpha-smooth muscle actin (alpha-SMA). The characterization of nanofibers showed that the PES membrane has nanoscale, porous, high surface area structure. These properties conferred higher exudate absorption capacity for the PES scaffold which is essential for effective wound healing. In vitro results indicated that the PES scaffold can support fibroblast proliferation similar to that with tissue culture polystyrene. Epithelial regeneration was expeditiously accelerated under PES as compared with Vasel...Continue Reading

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Methods Mentioned

BETA
scanning electron microscopy
fluorescence microscopy
SMA

Software Mentioned

[UNK]
Pro Plus
mini
image
BELSORP

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