PMID: 8610134Apr 2, 1996Paper

Accelerated evolution and Muller's rachet in endosymbiotic bacteria

Proceedings of the National Academy of Sciences of the United States of America
N A Moran

Abstract

Many bacteria live only within animal cells and infect hosts through cytoplasmic inheritance. These endosymbiotic lineages show distinctive population structure, with small population size and effectively no recombination. As a result, endosymbionts are expected to accumulate mildly deleterious mutations. If these constitute a substantial proportion of new mutations, endosymbionts will show (i) faster sequence evolution and (ii) a possible shift in base composition reflecting mutational bias. Analyses of 16S rDNA of five independently derived endosymbiont clades show, in every case, faster evolution in endosymbionts than in free-living relatives. For aphid endosymbionts (genus Buchnera), coding genes exhibit accelerated evolution and unusually low ratios of synonymous to nonsynonymous substitutions compared to ratios for the same genes for enterics. This concentration of the rate increase in nonsynonymous substitutions is expected under the hypothesis of increased fixation of deleterious mutations. Polypeptides for all Buchnera genes analyzed have accumulated amino acids with codon families rich in A+T, supporting the hypothesis that substitutions are deleterious in terms of polypeptide function. These observations are best exp...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S L O'NeillH M Robertson
Jun 1, 1989·Journal of Molecular Evolution·J JollèsA C Wilson
Jan 1, 1986·Journal of Molecular Evolution·P M Sharp, W H Li
Jan 1, 1987·Journal of Molecular Evolution·H Ochman, A C Wilson
Aug 1, 1988·Biochimie·H H Winkler, D O Wood
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N Sueoka
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A Muto, S Osawa
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C I Wu, W H Li
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·W J Swanson, V D Vacquier
Oct 13, 1994·Nature·F U Hartl
Jan 1, 1993·Annual Review of Biochemistry·J P Hendrick, F U Hartl
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Y LaiP Baumann
Jan 15, 1994·European Journal of Biochemistry·J Becker, E A Craig
Jul 1, 1993·Nucleic Acids Research·N LarsenC R Woese
Feb 1, 1993·Journal of Molecular Evolution·C Ohtaka, H Ishikawa
Mar 1, 1993·Journal of Molecular Evolution·A L Hughes, M K Hughes

❮ Previous
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Citations

Aug 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T Ohta
Dec 16, 2004·Journal of Molecular Evolution·Jennifer J Wernegreen, Daniel J Funk
Jan 18, 2006·Journal of Molecular Evolution·Leonard Nunney, Erin L Schuenzel
Feb 23, 2012·Applied Microbiology and Biotechnology·Guus Roeselers, Irene L G Newton
Oct 28, 2005·Current Microbiology·Seth Bordenstein, Rebeca B Rosengaus
Sep 3, 2008·Molecular Genetics and Genomics : MGG·Katarzyna Tomala, Ryszard Korona
May 25, 2010·Protoplasma·Emily L ClarkStephen F Hubbard
Aug 23, 2006·Genetica·Mats E Pettersson, Otto G Berg
Oct 24, 2003·Current Opinion in Microbiology·Nancy A Moran
Jun 5, 2002·Mechanisms of Ageing and Development·Gino A Cortopassi
Oct 5, 2001·Trends in Genetics : TIG·A MiraN A Moran
Aug 26, 1999·Trends in Genetics : TIG·H L RaceW Martin
Jul 8, 2000·Trends in Ecology & Evolution·N A Moran, J J Wernegreen
May 14, 1999·Trends in Ecology & Evolution·L D Hurst
May 11, 1999·Trends in Ecology & Evolution·E A HerreS A Rehner
Apr 12, 2003·Bio Systems·Anthony M PooleDavid Penny
Feb 20, 1998·Current Opinion in Genetics & Development·P R GilsonG I McFadden
Dec 23, 1999·Current Opinion in Genetics & Development·J O Andersson, S G Andersson
Aug 26, 1998·Trends in Microbiology·S G Andersson, C G Kurland
Jun 19, 2002·Molecular Phylogenetics and Evolution·Scott R SantosMary Alice Coffroth
Nov 15, 2003·Molecular Phylogenetics and Evolution·Keith L Adams, Jeffrey D Palmer
Jun 14, 2000·Current Opinion in Microbiology·N A Moran, P Baumann
Nov 26, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hugh D Loxdale, Gugs Lushai
Aug 6, 2004·Nature·Susan M Rosenberg, P J Hastings
May 20, 2011·Nature·Ariel Fernández, Michael Lynch
Mar 1, 2003·Nature Reviews. Genetics·Lindell Bromham, David Penny
Feb 13, 2008·Nature Reviews. Genetics·Andrés MoyaAmparo Latorre
Jun 10, 2009·Nature Reviews. Genetics·Jeferson Gross, Debashish Bhattacharya
Jun 3, 2010·Nature Reviews. Genetics·Christina Toft, Siv G E Andersson

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