Accelerated evolution of crotalinae snake venom gland serine proteases

FEBS Letters
M DeshimaruMotonori Ohno

Abstract

Eight cDNAs encoding serine proteases isolated from Trimeresurus flavoviridis (habu snake) and T. gramineus (green habu snake) venom gland cDNA libraries showed that nonsynonymous nucleotide substitutions have accumulated in the mature protein-coding regions to cause amino acid changes. Southern blot analysis of T. flavoviridis genomic DNAs using two proper probes indicated that venom gland serine protease genes form a multigene family in the genome. These observations suggest that venom gland serine proteases have diversified their amino acid sequences in an accelerating manner. Since a similar feature has been previously discovered in crotalinae snake venom gland phospholipase A2 (PLA2) isozyme genes, accelerated evolution appears to be universal in plural isozyme families of crotalinae snake venom gland.

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Citations

Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·Motonori OhnoShosaku Hattori
May 7, 2005·Toxicon : Official Journal of the International Society on Toxinology·Ken-ichi SaguchiShigesada Higuchi
Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·D Mebs
Jun 22, 2002·Toxicon : Official Journal of the International Society on Toxinology·Takahiko J FujimiToru Tamiya
Aug 15, 2002·Toxicon : Official Journal of the International Society on Toxinology·Ayako TaniMotonori Ohno
Jun 22, 2002·Toxicon : Official Journal of the International Society on Toxinology·Masaaki Kishimoto, Tomoko Takahashi
Feb 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Marina T AssakuraSolange M T Serrano
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Dec 5, 1998·Toxicon : Official Journal of the International Society on Toxinology·F S Markland
Feb 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·Y ChumanM Ohno
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Jun 23, 2009·Toxicon : Official Journal of the International Society on Toxinology·Alberto Alape-GirónJuan J Calvete

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