PMID: 11920748Mar 29, 2002Paper

Accelerated fluid bed drying using NIR monitoring and phenomenological modeling: method assessment and formulation suitability

Journal of Pharmaceutical Sciences
Peter L D WildfongKenneth R Morris

Abstract

The theory behind a fluidized bed fast-drying method is investigated as a potential timesaving process, which can reduce overall drying time compared to single-temperature cycles. The method teaches that for formulations in which heat transfer dominates the drying mechanism, an increase in temperature during the evaporative phase of drying decreases overall process time by 50%, without changing the physical properties of the active ingredient. The method is also examined in terms of its potential for cycle shortening for a given formulation. A combined expression for the overall drying profile has been developed and committed to a macro that facilitates the identification of phenomenological trends, which identify whether or not a process will benefit by using fast drying. The relationship and macro also allows prediction of time frames associated with a given set of dryer and formulation parameters.

References

Jul 29, 2000·Drug Development and Industrial Pharmacy·K R MorrisG E Peck

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Citations

May 19, 2005·Advanced Drug Delivery Reviews·Gabriele Reich
Dec 16, 2005·AAPS PharmSciTech·José D Pérez-RamosKenneth R Morris
Nov 22, 2011·Expert Opinion on Drug Delivery·Zhi Hui LohPaul W S Heng
May 5, 2004·Journal of Pharmaceutical Sciences·Steven J ShireJun Liu
Jun 24, 2003·Journal of Pharmaceutical Sciences·Tonglei LiKenneth R Morris
Oct 9, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anneleen BurggraeveThomas De Beer
Nov 3, 2009·Current Opinion in Biotechnology·Steven J Shire
Nov 3, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Caroline BuschmüllerJörg Breitkreutz
Apr 29, 2004·International Journal of Pharmaceutics·Sari AiraksinenJouko Yliruusi
Sep 24, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nicolas HeiglJohannes G Khinast

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