Accelerated generation of free radicals by iron oxide nanoparticles in the presence of an alternating magnetic field

RSC Advances
Robert J WydraJ Zach Hilt

Abstract

The surfaces of iron oxide nanoparticles are capable of catalytically generating reactive oxygen species (ROS) through the Fenton and Haber-Weiss reactions. Fenton chemistry has been shown to be temperature dependent with an increase in activity up to 40 °C and then a decrease above this temperature as the hydrogen peroxide degrades into oxygen and water which limits the reaction. When exposed to an alternating magnetic field (AMF), iron oxide nanoparticles absorb the energy from the magnetic field and convert it into heat. In this study, we observed an increase in the degradation of methylene blue when a suspension of magnetite nanoparticles (Fe3O4) was exposed to an AMF indicating there was an increase in the ROS generation in response to the AMF. The increase in ROS generation compared to the Arrhenius prediction was both time and concentration dependent; in which we observed a decrease in ROS enhancement with increased time of exposure and concentration. We postulate that the decrease is due to agglomeration in the presence of the field. As the nanoparticles agglomerate, there is a decrease in surface area per mass limiting the reaction rate.

References

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Citations

Sep 27, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anastasia K HauserJ Zach Hilt
May 5, 2017·International Journal of Molecular Sciences·Filippo CellaiMarco E M Peluso
Nov 4, 2017·Cellular and Molecular Life Sciences : CMLS·Martina GiannacciniVittoria Raffa
Apr 25, 2020·Frontiers in Chemistry·Małgorzata ŚwiętekDaniel Horák
Sep 12, 2019·Chemico-biological Interactions·Keywan MortezaeeAmirhossein Ahmadi
Apr 30, 2021·Environmental Science and Pollution Research International·Kumari SonuSai Siva Gorthi
Jul 27, 2021·Current Opinion in Chemical Engineering·Rishabh A ShahJames Zach Hilt
Jul 25, 2021·Biosensors & Bioelectronics·Amir M AshrafiVojtech Adam
Dec 15, 2016·ACS Applied Materials & Interfaces·Huijuan ZhangZhenzhong Zhang
Oct 16, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shehzahdi Shebbrin MoonshiHang Thu Ta

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