PMID: 8598354Mar 1, 1996Paper

Accelerated hyperfractionated radiotherapy for malignant gliomas

International Journal of Radiation Oncology, Biology, Physics
J M BuattiF J Bova

Abstract

To evaluate accelerated hyperfractionated radiotherapy for the treatment of malignant gliomas. Between April 1985 and June 1994, 70 adult patients with pathologically confirmed malignant glioma (75% glioblastoma multiforme, 25% anaplastic astrocytoma) suitable for high-dose therapy were selected for treatment with accelerated hyperfractionated radiotherapy, 1.5 Gy twice daily to a total target dose of 60 Gy. Two patients were excluded from analysis (one patient had a fatal pulmonary embolism after 18 Gy; one patient discontinued therapy after 28.5 Gy against medical advice and without sequelae or progression). The 68 patients in the study group had a median age of 52 years and a median Karnofsky performance status of 90. Stereotactic implant (125I) or stereotactic radiosurgery boosts were delivered to 16 patients (24%) in the study group. Minimum follow-up was 6 months. Median survival was 13.8 months and median progression-free survival was 7.4 months. The absolute Kaplan-Meier survival rate was 16% at 2 years and 4% at 5 years. Multivariate analysis for the prognostic impact of age, gender, histology, Karnofsky performance status, symptomatology, surgical resection vs. biopsy, and boost vs. nonboost therapy revealed that Karn...Continue Reading

References

Oct 1, 1979·International Journal of Radiation Oncology, Biology, Physics·M D WalkerG E Sheline
Oct 1, 1979·International Journal of Radiation Oncology, Biology, Physics·O M SalazarR Pizzutiello
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·D C ShrieveV A Levin
Feb 1, 1992·Journal of Neurosurgery·R C FlorellJ G Cairncross
Apr 1, 1991·International Journal of Radiation Oncology, Biology, Physics·D E LinstadtW M Wara
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·L W Davis
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·V A Marcial-VegaS E Order
Jan 1, 1985·International Journal of Radiation Oncology, Biology, Physics·M V WilliamsJ F Fowler
Apr 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J M BuattiW M Mendenhall
Aug 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D G GonzálezJ Bernier
Feb 1, 1994·Neurosurgery·M SalcmanS Kulik
Sep 30, 1993·International Journal of Radiation Oncology, Biology, Physics·C J McGinnT J Kinsella
Jan 15, 1993·International Journal of Radiation Oncology, Biology, Physics·E J Hall, D J Brenner

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Citations

Aug 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M GencI L Atahan
Apr 9, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tom B JohannesenHenry Hirschberg
Jun 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C Fallai, P Olmi
Jul 1, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B JeremicJ Aleksandrovic
Jan 7, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J LutterbachW Hinkelbein
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Ravi D RaoJan C Buckner
Oct 6, 1997·International Journal of Radiation Oncology, Biology, Physics·K S CondraA L Rhoton
Feb 25, 1999·International Journal of Radiation Oncology, Biology, Physics·M BradaS Ashley
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R OrecchiaU Veronesi
Feb 3, 2005·American Journal of Clinical Oncology·Teri S KatzChristopher G Morris
Mar 4, 2014·PloS One·Juan Carlos López AlfonsoDirk Drasdo
Dec 30, 1998·International Journal of Radiation Oncology, Biology, Physics·S VillàF Graus
Jun 2, 2006·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·David Mathieu, David Fortin
Mar 25, 2005·Acta Oncologica·Tejpal Gupta, Ketayun Dinshaw
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R MiralbellR O Mirimanoff
May 15, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M van KampenM Wannenmacher
Jan 8, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·O LangM L Sautter-Bihl

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