Accelerated hypofractionated radiotherapy as adjuvant regimen after conserving surgery for early breast cancer: interim report of toxicity after a minimum follow up of 3 years.

Journal of Experimental & Clinical Cancer Research : CR
Paola PinnaròLidia Strigari

Abstract

Accelerated hypofractionation is an attractive approach for adjuvant whole breast radiotherapy. In this study we evaluated the adverse effects at least 3 years post an accelerated hypofractionated whole breast radiotherapy schedule. From October 2004 to March 2006, 39 consecutive patients aged over 18 years with pTis, pT1-2, pN0-1 breast adenocarcinoma who underwent conservative surgery were treated with an adjuvant accelerated hypofractionated radiotherapy schedule consisting of 34 Gy in 10 daily fractions over 2 weeks to the whole breast, followed after 1 week by an electron boost dose of 8 Gy in a single fraction to the tumour bed. Skin and lung radiation toxicity was evaluated daily during therapy, once a week for one month after radiotherapy completion, every 3 months for the first year and from then on every six months. In particular lung toxicity was investigated in terms of CT density evaluation, pulmonary functional tests, and clinical and radiological scoring. Paired t-test, Chi-square test and non-parametric Wilcoxon test were performed. After a median follow-up of 43 months (range 36-52 months), all the patients are alive and disease-free. None of the patients showed any clinical signs of lung toxicity, no CT-lung t...Continue Reading

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Aug 27, 2014·International Journal of Surgery·Alfonso ReginelliSalvatore Cappabianca
Nov 2, 2011·The Breast : Official Journal of the European Society of Mastology·Jonathan D Schoenfeld, Jay R Harris
Dec 25, 2015·International Journal of Radiation Oncology, Biology, Physics·Stuti AhlawatAtif J Khan
Jan 16, 2014·Journal of Experimental & Clinical Cancer Research : CR·Valeria LandoniPaola Pinnarò
Jan 16, 2014·Journal of Experimental & Clinical Cancer Research : CR·Vicente BruzzanitiLidia Strigari
Jan 26, 2012·Journal of Experimental & Clinical Cancer Research : CR·Elisabetta FalvoPaola Pinnarò
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Nov 12, 2016·Aging Clinical and Experimental Research·Francesca Maria GiuglianoPaolo Muto
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Moujhuri NandiSanjoy Chatterjee

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