PMID: 7541140Jun 20, 1995Paper

Accelerated induction of experimental allergic encephalomyelitis in PL/J mice by a non-V beta 8-specific superantigen

Proceedings of the National Academy of Sciences of the United States of America
J M SoosH M Johnson

Abstract

Superantigens such as the staphylococcal enterotoxins can play an important role in exacerbation of autoimmune disorders such as experimental allergic encephalomyelitis (EAE) in mice. In fact, superantigens can reactivate EAE in PL/J mice that have been sensitized to rat myelin basic protein (MBP). The T-cell subset predominantly responsible for disease in PL/J mice bears the V beta 8+ T-cell antigen receptor (TCR). The question arises as to whether T cells bearing other V beta specificities are involved in induction or reactivation of EAE with superantigen. Thus, we have investigated the ability of a non-V beta 8-specific superantigen, staphylococcal enterotoxin A (SEA) (V beta specificities 1, 3, 10, 11, and 17), to induce EAE in PL/J mice that have been previously protected from disease by anergy and deletion of V beta 8+ T cells. PL/J mice were first pretreated with the V beta 8-specific superantigen staphylococcal enterotoxin B (SEB) and then immunized with MBP. These mice exhibited V beta 8-specific anergy and depletion and did not develop EAE, even when further treated with SEB. However, administration of SEA to these same mice induced an initial episode of EAE which was characterized by severe hindleg paralysis and acce...Continue Reading

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Citations

Jan 1, 1996·Springer Seminars in Immunopathology·S BrockeL Steinman
Sep 2, 1998·Current Opinion in Immunology·B A Torres, H M Johnson
Jan 21, 2014·Annual Review of Immunology·Lawrence Steinman
Sep 29, 2004·Journal of the Neurological Sciences·Wendy GilmoreJorge Correale
Dec 1, 1996·Immunological Reviews·T Renno, H Acha-Orbea
Nov 6, 2015·Frontiers in Immunology·Andrew J Steelman
May 22, 2001·Experimental Biology and Medicine·B A TorresH M Johnson
Jan 8, 2004·Experimental Biology and Medicine·J D LuttonT C Rodman
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara A TorresHoward M Johnson

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