PMID: 9548726May 23, 1998Paper

Accelerated nerve regeneration mediated by Schwann cells expressing a mutant form of the POU protein SCIP

The Journal of Cell Biology
M GondréD E Weinstein

Abstract

After injury, the peripheral nervous system (PNS) is capable of full regeneration and recovery of function. Many molecular events that are the hallmarks of the regenerating PNS are recapitulations of developmental processes. The expression of one such molecule, the POU transcription factor suppressed cAMP-inducible POU protein (SCIP), is required for the establishment of normal nerves and is reexpressed during regeneration. Here we describe markedly accelerated regeneration and hypertrophy of both myelin and axons in transgenic mice that express an amino-terminal deletion of the SCIP molecule. This mutant SCIP molecule retains the POU-specific and POU homeodomain moieties, which allow for both DNA binding and some protein-protein interaction. We demonstrate that the transgene indirectly effects dramatic axonal changes. This is the first demonstration of a genetically controlled acceleration of neural regeneration.

References

May 1, 1975·Journal of Neuropathology and Experimental Neurology·D H SnyderC S Raine
Nov 1, 1990·Trends in Neurosciences·J WalterF Bonhoeffer
Jul 1, 1988·Trends in Neurosciences·S B KaterJ Connor
Jan 8, 1985·The Journal of Comparative Neurology·I G McQuarrie
Aug 2, 1988·Brain Research·C B JenqR E Coggeshall
Jan 1, 1986·Neuropathology and Applied Neurobiology·S M Hall
Sep 1, 1986·Journal of Neurosurgery·J W Fawcett, R J Keynes
Aug 1, 1986·Journal of Neurocytology·F ScaravilliR Myers
Apr 1, 1973·Journal of Neuropathology and Experimental Neurology·A J AguayoG M Bray
Dec 1, 1980·The Journal of Cell Biology·R W Gundersen, J N Barrett
Dec 12, 1983·Brain Research·C IdeS Onodera
May 1, 1995·Journal of Neurocytology·T O CrawfordJ D Glass
Jul 1, 1993·Mechanisms of Development·E S MonukiG Lemke
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·T K MorrisseyR P Bunge
May 1, 1994·Molecular and Cellular Biology·I FausE Fuchs
Jul 26, 1996·Science·M JaegleD Meijer
Oct 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C BeaulieuP S Allen
Jan 1, 1997·Molecular and Cellular Neurosciences·P R MaycoxG Lemke
Jan 7, 1998·Journal of Neuroscience Research·P L BieriD E Weinstein

❮ Previous
Next ❯

Citations

Jul 30, 2009·Cell and Tissue Research·Yujun WeiXiufang Zhang
Aug 11, 1999·Trends in Neurosciences·K R Jessen, R Mirsky
Sep 2, 2005·Nature Neuroscience·Nam LeJeffrey Milbrandt
Apr 21, 2001·Molecular and Cellular Neurosciences·R WuD E Weinstein
Mar 10, 2004·International Review of Neurobiology·Maria Ilia
Jul 26, 2005·Molecular and Cellular Neurosciences·Kyoko ItohVance Lemmon
Apr 23, 2008·Current Protocols in Neuroscience·D E Weinstein, R Wu
Apr 29, 1999·Brain Pathology·R Mirsky, K R Jessen
Jun 20, 2017·F1000Research·Mary R HannamanJoseph L Bryant
Feb 25, 2021·Journal of the Peripheral Nervous System : JPNS·Alejandro PeinadoCharles K Abrams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.