Accelerated partial breast irradiation: initial experience with the Intrabeam System

Surgical Oncology
R L ElliottM C Elliott

Abstract

Failure after breast conserving surgery (BCS) and total breast irradiation usually occurs at the site of the original tumor. This has caused an increased interest in accelerated partial breast irradiation (APBI), because if radiation is delivered directly to the tumor bed there should be better local control. Patients greater than age 50 with core biopsy confirmed invasive ductal carcinoma were enrolled. They had preoperative ultrasound defining margins of less than 3.5 cm. Intraoperative ultrasound was also performed in an effort to ensure good surgical margins. After excision of the tumor, intraoperative radiotherapy (IORT) with the Intrabeam System was delivered to the tumor bed. The procedure has been performed on 67 patients. Sixty-one patients had it with the original surgery, while 6 had the procedure after re-exploration of the segmental mastectomy site. Because of the final pathology (surgical margins, tumor biology, and nodal status) 4 patients later had total mastectomy and 11 received total breast irradiation. When total breast irradiation is done the IORT serves as the radiation boost. The cosmetic results have been good to excellent, and there have been no serious surgical or radiation complications. To date there...Continue Reading

References

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Citations

Apr 26, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E C KoB S Rosenstein
Sep 8, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Michał FalcoAndrzej Kram
May 3, 2012·Radiology Research and Practice·Ronald RiveraDennis R Holmes
Feb 18, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Maxime Goubert, Laure Parent
Dec 18, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B ElsbergerA Evans
Mar 7, 2014·Expert Review of Medical Devices·Kapila Kalakota, William Small
Jan 10, 2012·Current Opinion in Obstetrics & Gynecology

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