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Accelerated protein evolution analysis reveals genes and pathways associated with the evolution of mammalian longevity

Age

Dec 30, 2011

Yang Li, J P de Magalhães

Abstract

The genetic basis of the large species differences in longevity and aging remains a mystery. Thanks to recent large-scale genome sequencing efforts, the genomes of multiple species have been sequenced and can be used for cross-species comparisons to study species divergence in longevity...read more

Mentioned in this Paper

Biochemical Pathway
Proteasome Pathway
LGV1
Cholesterol Catabolic Process
Genome
DNA Repair
Ubiquitin
Gene Products, Protein
Senility
Ubiquitin Activity
1
3
72
Paper Details
References
  • References46
  • Citations20
12345
  • References46
  • Citations20
12

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Accelerated protein evolution analysis reveals genes and pathways associated with the evolution of mammalian longevity

Age

Dec 30, 2011

Yang Li, J P de Magalhães

PMID: 22205409

DOI: 10.1007/s11357-011-9361-y

Abstract

The genetic basis of the large species differences in longevity and aging remains a mystery. Thanks to recent large-scale genome sequencing efforts, the genomes of multiple species have been sequenced and can be used for cross-species comparisons to study species divergence in longevity...read more

Mentioned in this Paper

Biochemical Pathway
Proteasome Pathway
LGV1
Cholesterol Catabolic Process
Genome
DNA Repair
Ubiquitin
Gene Products, Protein
Senility
Ubiquitin Activity
1
3
72

Similar Papers Found In These Feeds

DNA Repair

DNA repair is critical to prevent detrimental mutations and maintain genomic stability that can otherwise lead to disease and disability. There are a number of different mechanisms of repair including base excision repair, direct repair, nucleotide excision repair and double-strand break repair. Discover the latest research on DNA repair here.

Ubiquitin System

Ubiquitin is a small regulatory protein that is attached to proteins as a post-translational modification in a process known as ubiquitination to regulate protein turnover, location, or activity. Here is the latest research on the ubiquitin system.

Related Papers

Ageing Research Reviews

Systems approaches to the networks of aging

Ageing Research ReviewsAugust 15, 2006
Andres KrieteGeoffrey B West
Nihon rinsho. Japanese journal of clinical medicine

Anti-aging drugs

Nihon rinsho. Japanese journal of clinical medicineJuly 14, 2009
Atsushi Kuno, Yoshiyuki Horio
Paper Details
References
  • References46
  • Citations20
12345
  • References46
  • Citations20
12
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