Accelerated repetitive transcranial magnetic stimulation in the treatment of depression

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Paul B FitzgeraldZafiris J Daskalakis

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is increasingly used clinically in the treatment of patients with major depressive disorder (MDD). However, rTMS treatment response can be slow. Early research suggests that accelerated forms of rTMS may be effective but no research has directly evaluated a schedule of accelerated rTMS compared to standard rTMS. To assess the efficacy of accelerated rTMS compared to standard daily rTMS., 115 outpatients with MDD received either accelerated rTMS (n = 58) (i.e., 63,000 high frequency rTMS pulses delivered as 3 treatments per day over 3 days in week 1, 3 treatments over 2 days in week 2 and 3 treatments on a single day in week 3) or standard rTMS (n = 57) (i.e., 63,000 total high frequency rTMS pulses delivered over 5 days per week for 4 weeks) following randomization. There were no significant differences in remission or response rates (p > 0.05 for all analyses) or reduction in depression scores (Time by group interaction (F (5, 489.452) = 1.711, p = 0.130) between the accelerated and standard rTMS treatment groups. Accelerated treatment was associated with a higher rate of reported treatment discomfort. It is feasible to provide accelerated rTMS treatment for outpatients with ...Continue Reading

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Apr 10, 2016·Depression and Anxiety·Paul B FitzgeraldZafiris J Daskalakis

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Citations

Jun 18, 2019·Clinical Pharmacology and Therapeutics·Alisson P Trevizol, Daniel M Blumberger
Jul 10, 2019·Expert Review of Neurotherapeutics·Leo ChenPaul B Fitzgerald
May 26, 2020·European Archives of Psychiatry and Clinical Neuroscience·Igor FilipčićŽarko Bajić
Nov 16, 2018·Frontiers in Psychology·Chris Baeken
Jan 29, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Soo-Jeong KimJai Sung Noh
Jan 7, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurUlf Ziemann
Oct 29, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Laís B RazzaAndré R Brunoni
May 16, 2020·Brain Stimulation·Marom BiksonHamed Ekhtiari
Apr 3, 2021·The Australian and New Zealand Journal of Psychiatry·Gin S MalhiBill Lyndon
Apr 4, 2021·Brain Sciences·Lekshmy Sudha Kumari, Abbas Z Kouzani
Jan 15, 2019·Journal of Affective Disorders·Ali AmadThomas Fovet
Jul 13, 2021·Frontiers in Human Neuroscience·Mehmet Utku KucukerPaul E Croarkin
Jul 2, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diego Freitas TavaresRicardo Alberto Moreno
Jul 21, 2021·Asian Journal of Psychiatry·Sangha Mitra GodiSai Krishna Tikka
Jan 4, 2022·Journal of Child and Adolescent Psychopharmacology·Bhedita J SeewooJennifer Rodger

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