Accelerated split-course (type B) thoracic radiation therapy plus vinorelbine/carboplatin combination chemotherapy in stage III inoperable non-small cell lung cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
R V IaffaioliP Muto

Abstract

43 patients with stage III NSCLC (non-small cell lung cancer) entered a phase II study aimed at evaluating the toxicity and the activity of a combined modality programme including an accelerated split-course schedule (type B) of thoracic radiation therapy and a combination chemotherapy with vinorelbine and carboplatin. An objective response was achieved in 18/42 evaluable patients (5 complete and 13 partial responses), for an overall response rate of 43% (95% confidence interval, 28-58%). Four complete responses had a duration which exceeded 16 months. Treatment was well tolerated; grade III myelotoxicity occurred in only 14% of patients and treatment was delayed in only 2 cases because of grade 3 oesophagitis. Both tolerability and efficacy data suggest that this regimen holds promise for the treatment of patients with stage III NSCLC.

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Citations

Nov 21, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K FukuokaK Nishio
Dec 18, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·O Caffo
Dec 12, 2001·Critical Reviews in Oncology/hematology·M S AaproJ B Vermorken
Aug 30, 2008·The Annals of Thoracic Surgery·Martin J EdelmanMark J Krasna
Mar 10, 2004·Hematology/oncology Clinics of North America·Yuhchyau Chen, Paul Okunieff

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