PMID: 15237711Jul 9, 2004Paper

Accelerated versus slowly progressive forms of puberty in girls with precocious and early puberty. Gonadotropin suppressive effect and final height obtained with two different analogs

Journal of Pediatric Endocrinology & Metabolism : JPEM
Roberto LanesSalomon Jakubowicz

Abstract

To distinguish which children with precocious puberty (PP) and early puberty (EP) should be treated and which followed without therapy. To determine the effect of GnRH analog treatment on the final height of treated patients and compare the effect of two different analogs on gonadotropin suppression and final height. Sixteen females with PP or EP with a mean chronological age (CA) of 8.8 +/- 1.4 years and a mean bone age (BA) of 10.8 +/- 1.3 years were treated for a mean of 2.7 +/- 1.0 years with a GnRH analog (triptorelin or leuprolide acetate; group A), while 21 girls with a mean CA of 8.5 +/- 1.0 years, a mean BA of 9.7 +/- 1.4 years and a predicted adult height of >155 cm were followed without therapy (group B). Criteria for treatment were one of: a. predicted adult height (PAH) of <155 cm initially or at any time during follow up; b. PAH over 155 cm with a dramatic decrease in PAH over a 6-month follow-up period; c. advanced and rapidly progressing breast development for age (Tanner 3 before the age of 9 years). GnRHa therapy suppressed gonadotropins in group A, while gonadotropins increased gradually in group B. Height velocity (HV) decreased in group A, while it remained accelerated in group B; BA increased a mean of 1.7...Continue Reading

References

Dec 11, 1991·The Journal of Clinical Endocrinology and Metabolism·K E OerterG B Cutler
Sep 1, 1990·The Journal of Pediatrics·M KreiterL L Levitsky
Feb 1, 1989·The Journal of Pediatrics·P A Lee, J G Page
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Apr 10, 2002·Clinical Endocrinology·Christopher J H Kelnar, Richard Stanhope

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Citations

Apr 26, 2006·Expert Opinion on Investigational Drugs·Torsten Tuvemo
Jan 31, 2009·Clinical Endocrinology·Frances MouatWayne S Cutfield
Jun 21, 2013·Expert Opinion on Pharmacotherapy·Silvano Bertelloni, Giampiero I Baroncelli
Jun 30, 2018·Expert Review of Clinical Pharmacology·Silvano BertelloniDiego Peroni
Mar 1, 2013·Annals of Pediatric Endocrinology & Metabolism·Shin-Ae YoonSung-Cheol Yun
Apr 3, 2020·Archives of Endocrinology and Metabolism·Özge YücePeyami Cinaz

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