Accelerated Versus Standard Corneal Cross-Linking for Progressive Keratoconus: A Meta-Analysis of Randomized Controlled Trials.

Cornea
Hidenaga Kobashi, Kazuo Tsubota

Abstract

To compare the clinical results of accelerated corneal collagen cross-linking (ACXL) to standard corneal collagen cross-linking (SCXL) in progressive keratoconus by summarizing randomized controlled trials using a meta-analysis. Trials meeting the selection criteria were quality appraised, and data were extracted by 2 independent authors. A comprehensive search was performed using the Cochrane methodology to evaluate the clinical outcomes of ACXL and SCXL for treating progressive keratoconus. Estimates were evaluated by weighted mean difference (WMD) and 95% confidence interval (CI) for absolute changes of the outcomes during 12-month observation periods. Postoperative demarcation line depth was also compared. We identified 6 randomized controlled trials that met the eligibility criteria for this meta-analysis. SCXL resulted in a significantly better outcome in postoperative changes in best spectacle-corrected visual acuity (WMD = -0.02; 95% CI, -0.03 to -0.01; P < 0.0001); however, the small differences may not be clinically significant. ACXL provided a significantly better improvement of cylindrical refraction after the 1-year follow-up (WMD = 0.15; 95% CI, 0.05-0.26; P = 0.005). Demarcation line depth at 1 month after SCXL w...Continue Reading

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Citations

Nov 22, 2019·Clinical & Experimental Ophthalmology·Gerard Sutton, Chris Hodge
Dec 17, 2020·Asia-Pacific Journal of Ophthalmology·Colin Chan
Feb 13, 2021·Journal of Refractive Surgery·Farhad HafeziNikki L Hafezi
Apr 16, 2021·PloS One·Federica BoschettiAnna Pandolfi
May 10, 2021·Current Opinion in Ophthalmology·Hamza PashaVishal Jhanji
Jul 3, 2021·Journal of Clinical Medicine·Hidenaga Kobashi The Keratoconus Study Group Of Japan
Aug 6, 2021·Frontiers in Pharmacology·Duoduo WuChris Hong Long Lim
Aug 28, 2021·International Ophthalmology·Sebastiano SerraoMarco Lombardo

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