Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs

Journal of Controlled Release : Official Journal of the Controlled Release Society
Suwei ZhuTatiana Segura

Abstract

Injectable hydrogel matrices take the shape of a wound cavity and serve as scaffold for tissue repair and regeneration. Yet these materials are generally hydrophilic, limiting the incorporation of poorly water soluble, hydrophobic drugs. Here we show this shortcoming is circumvented through a star-shaped amphiphilic block copolymer comprising poly(ethylene glycol) and poly (propylene sulfide). This star-shaped amphiphilic polymer self-assembles in an aqueous medium into a physically stable hydrogel and effectively dissolves hydrophobic molecules delivering them at therapeutic doses. The self assembled hydrogel is a robust three-dimensional scaffold in vivo effectively promoting cellular infiltration, reducing inflammation, and wound clsoure. When combined with a hydrophobic BRAF inhibitor that promotes paradoxical mitogen-activated protein kinase (MAPK) activation in keratinocytes and wound closure, our self assembled scaffold supported dermal wound closure at a reduced drug dosage compared to administering the drug in dimethyl sulfoxide (DMSO) without a polymeric matrix. This family of star-shaped amphiphilic polymers delivers poorly water soluble active agents at a fraction of generally required dosage for efficacy and suppor...Continue Reading

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Citations

Sep 19, 2019·Current Drug Delivery·Xiaosong YangXiaoguang Liu
Aug 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuejun YaoChangyou Gao
Dec 20, 2018·Macromolecular Bioscience·Laura Saunders, Peter X Ma
Jun 5, 2019·Journal of Cellular Physiology·Xiaqing YuZhongwei Lv
Aug 26, 2020·International Journal of Biological Macromolecules·Ting WangJinming Zhang
Jun 13, 2021·Macromolecular Bioscience·Hui Wen Yong, Ashok Kakkar
Apr 30, 2021·Cancer Discovery·Mario E LacoutureAntoni Ribas

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