Accelerating access to quality TB care for pediatric TB cases through better diagnostic strategy in four major cities of India

PloS One
Neeraj RaizadaSanjay Sarin

Abstract

Diagnosis of TB in children is challenging, and is largely based on positive history of contact with a TB case, clinical and radiological findings, often without microbiological confirmation. Diagnostic efforts are also undermined by challenges in specimen collection and the limited availability of high sensitivity, rapid diagnostic tests that can be applied with a quick turnaround time. The current project was undertaken in four major cities of India to address TB diagnostic challenges in pediatric population, by offering free of cost Xpert testing to pediatric presumptive TB cases, thereby paving the way for better TB care. A high throughput lab was established in each of the four project cities, and linked to various health care providers across the city through rapid specimen transportation and electronic reporting linkages. Free Xpert testing was offered to all pediatric (0-14 years) presumptive TB cases (both pulmonary and extra-pulmonary) seeking care at public and private health facilities. The current project enrolled 42,238 pediatric presumptive TB cases from April, 2014 to June, 2016. A total of 3,340 (7.91%, CI 7.65-8.17) bacteriologically confirmed TB cases were detected, of which 295 (8.83%, CI 7.9-9.86) were rifa...Continue Reading

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Citations

Aug 28, 2020·The Cochrane Database of Systematic Reviews·Alexander W KayAnna M Mandalakas
Oct 1, 2020·The American Journal of Tropical Medicine and Hygiene·Micaela SandovalAnna M Mandalakas
Jun 9, 2021·The Indian Journal of Tuberculosis·Neeraj RaizadaAakshi Kalra
Sep 3, 2021·World Journal of Pediatrics : WJP·Tian-Zhuo YuGao-Yi Yang

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