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Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

SLAS Discovery

Feb 21, 2019

Carolina B MoraesSheraz Gul

Abstract

According to the World Health Organization, more than 1 billion people are at risk of or are affected by neglected tropical diseases. Examples of such diseases include trypanosomiasis, which causes sleeping sickness; leishmaniasis; and Chagas disease, all of which are prevalent in Afric...read more

Mentioned in this Paper

Trypanosomiasis
toxicant
Cessation of Life
Inhibitors
Leishmaniasis
Persons
Evaluation
World Health Organization
Cell Growth
Pharmacologic Substance
2
19
Paper Details
References
  • References31
  • Citations1
1234
  • References31
  • Citations1
1

Similar Papers Found In These Feeds

Leishmaniasis

Leishmaniasis is a parasitic infection caused by Leishmania species and transmitted though the bite of phlebotomine sand flies. It is considered to be a neglected tropical disease. Leishmaniasis is often categorized as cutaneous (presenting with skin sores, mucocutaneous (presenting with skin and mucosal lesions), and visceral (affecting multiple organs). Find the latest research on leishmaniasis here.

Chagas Disease

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. Discover the latest research on chagas disease here.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Chagas Disease

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. In the early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes, headaches, or local swelling at the site of the bite. After 8–12 weeks, individuals enter the chronic phase of disease and in 60–70% it never produces further symptoms.The other 30–40% of people develop further symptoms 10–30 years after the initial infection, including enlargement of the ventricles of the heart in 20–30%, leading to heart failure. An enlarged esophagus or an enlarged colon may also occur in 10% of people. Discover the latest research on Chagas disease here.

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Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

SLAS Discovery

Feb 21, 2019

Carolina B MoraesSheraz Gul

PMID: 30784368

DOI: 10.1177/2472555218823171

Abstract

According to the World Health Organization, more than 1 billion people are at risk of or are affected by neglected tropical diseases. Examples of such diseases include trypanosomiasis, which causes sleeping sickness; leishmaniasis; and Chagas disease, all of which are prevalent in Afric...read more

Mentioned in this Paper

Trypanosomiasis
toxicant
Cessation of Life
Inhibitors
Leishmaniasis
Persons
Evaluation
World Health Organization
Cell Growth
Pharmacologic Substance
2
19

Similar Papers Found In These Feeds

Leishmaniasis

Leishmaniasis is a parasitic infection caused by Leishmania species and transmitted though the bite of phlebotomine sand flies. It is considered to be a neglected tropical disease. Leishmaniasis is often categorized as cutaneous (presenting with skin sores, mucocutaneous (presenting with skin and mucosal lesions), and visceral (affecting multiple organs). Find the latest research on leishmaniasis here.

Chagas Disease

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. Discover the latest research on chagas disease here.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry

Screening a Natural Product-Based Library against Kinetoplastid Parasites

Molecules : a Journal of Synthetic Chemistry and Natural Product ChemistryOctober 13, 2017
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PLoS Neglected Tropical Diseases

Mining a cathepsin inhibitor library for new antiparasitic drug leads

PLoS Neglected Tropical DiseasesMay 17, 2011
Kenny K H AngAdam R Renslo
Paper Details
References
  • References31
  • Citations1
1234
  • References31
  • Citations1
1
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