Accelerating fragment-based library generation by coupling high-performance photoreactors with benchtop analysis.

Beilstein Journal of Organic Chemistry
Quentin LefebvreThomas C Fessard

Abstract

Herein we report a workflow coupling photoredox-nickel dual-catalyzed N-arylation reactions to benchtop analysis for the efficient generation of fragment-based libraries. Technological advances in photoreactor design facilitated reliable and reproducible experimentation. Knowledge on the reactivity under previously reported reaction conditions of spirocyclic and strained heterocyclic building blocks, viewed as chemistry informers, could thus be rapidly accessed, identifying privileged or challenging scaffolds and paving the way for further exploration.

References

Apr 2, 2008·Chemical Communications : Chem Comm·M Baidya, Herbert Mayr
Jul 18, 2008·Organic Letters·Johannes Burkhard, Erick M Carreira
Oct 16, 2009·Journal of Medicinal Chemistry·Frank LoveringChristine Humblet
Jun 15, 2010·Angewandte Chemie·Johannes A BurkhardErick M Carreira
Jan 18, 2011·Organic Letters·Carine GuérotErick M Carreira
Oct 20, 2011·Organic Letters·Dong Bo LiErick M Carreira
Jul 9, 2014·Chemical Reviews·Erick M Carreira, Thomas C Fessard
Jan 20, 2015·Nature Methods·Jonathan B GrimmLuke D Lavis
Jun 25, 2016·Science·Emily B CorcoranDavid W C MacMillan
Aug 24, 2017·Angewandte Chemie·Chao LiPhil S Baran
May 23, 2018·Journal of the American Chemical Society·Chern-Hooi LimGarret M Miyake
Nov 7, 2018·Angewandte Chemie·Simon L RösslerErick M Carreira
Jan 19, 2019·Chemical Communications : Chem Comm·Maud BollenbachChristophe Salomé

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Citations

Sep 25, 2021·Chemical Reviews·Lisa CandishSebastian Keess

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

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