PMID: 9442985Jan 1, 1997Paper

Accelerating response in geriatric depression: a pilot study combining sleep deprivation and paroxetine

Depression and Anxiety
G M BumpD J Kupfer

Abstract

Elderly depressed patients often require an average of 12 weeks of pharmacotherapy before attaining remission. The delay between treatment initiation and remission may decrease compliance and prolongs suffering; hence, interventions that decrease the time to onset of antidepressant activity are needed. Our objective was to evaluate, in an open trial, the use of one night of total sleep deprivation combined with paroxetine to accelerate antidepressant response in elderly patients. Thirteen elderly patients with major depression were sleep-deprived for one night and started paroxetine on the night of recovery sleep. Patients were followed for twelve weeks, and clinical improvement was rated using the 17-item Hamilton Depression Rating Scale and a version of the Hamilton modified for sleep deprivation studies. 8/13 (62%) patients experienced significant improvement of depressive symptoms by 2 weeks. Within 12 weeks 11/13 (85%) patients responded to the combination of sleep deprivation and paroxetine. Median response time was 2 weeks. Clinical response at 12 weeks was correlated with changes in Sleep Deprivation Depression Rating Scale Scores between baseline and recovery sleep. In an open trial, the combined use of total sleep dep...Continue Reading

Citations

Dec 14, 2004·Journal of Psychiatric Research·Stephen K BrannanGary D Tollefson
Jan 18, 2003·Sleep Medicine Reviews·Lisa Lustberg, Charles F. Reynolds
Jul 8, 2011·The International Journal of Neuropsychopharmacology·Blynn G Bunney, William E Bunney
Jul 5, 2011·Expert Review of Neurotherapeutics·Sara Dallaspezia, Francesco Benedetti
Aug 4, 2011·Neuropsychobiology·Francesco Benedetti, Cristina Colombo
Oct 20, 2015·Current Psychiatry Reports·Sara DallaspeziaFrancesco Benedetti

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