Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37

The Journal of Clinical Investigation
Lintao Qu, Michael J Caterina

Abstract

Resolution of inflammation is a critical process that is facilitated by specialized proresolving mediators (SPMs). In this issue, Bang et al. show that the G protein-coupled receptor GPR37 is a receptor for one such SPM, neuroprotectin D1. They also show that GPR37 activation in macrophages enhances phagocytosis, shifts cytokine release toward an antiinflammatory profile, and thereby helps to reverse inflammatory pain.

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Citations

Nov 13, 2019·Expert Opinion on Therapeutic Targets·Pei ShangJiachun Feng
Oct 15, 2019·Frontiers in Pharmacology·Corinne JoffreSophie Layé
Feb 5, 2021·International Journal of Molecular Sciences·Jessica Aijia LiuChi Wai Cheung
Sep 17, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Rafaela Nasser VeigaDaniela Fiori Gradia
Oct 12, 2021·The Proceedings of the Nutrition Society·Rasha N M Saleh, Anne Marie Minihane

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