PMID: 8957545Jan 1, 1996Paper

Acceleration of contraction by beta-adrenoceptor stimulation is greater in ventricular myocytes from failing than non-failing human hearts

Basic Research in Cardiology
S E HardingP A Poole-Wilson

Abstract

Myocytes from failing human ventricle contract and relax more slowly than those from non-failing. This has been suggested to result from the lowering of basal cyclic AMP level in failing myocardium, and the consequent withdrawal of a tonic lusitropic effect. We present data to support this hypothesis by demonstrating that the acceleration of contraction and relaxation by beta-adrenoceptor stimulation is greater in myocytes from failing than non-failing heart. This is despite the desensitisation of the inotropic effect of isoprenaline in the same failing cells. Following beta-adrenoceptor stimulation, speeds of contraction and relaxation are normalised in myocytes from failing heart, with final values not significantly different from non-failing.

References

Nov 13, 1992·European Journal of Pharmacology·S E HardingP A Poole-Wilson
Jul 1, 1989·Journal of Cardiovascular Pharmacology·W DanielsenP Kalmár
Aug 1, 1995·Cardiovascular Research·F del MonteS E Harding
Dec 1, 1994·European Heart Journal·V Regitz-ZagrosekE Fleck

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Citations

Aug 29, 1996·European Journal of Pharmacology·D G WynneS E Harding
May 10, 2001·Journal of Molecular and Cellular Cardiology·K DaviaS E Harding
Jan 27, 2015·Cardiovascular Research·Thomas EschenhagenBjorn C Knollmann
Jan 19, 2012·PloS One·Eric N RittmeyerChristopher C Austin
Mar 28, 2007·Heart Failure Clinics·Sian E Harding
Mar 24, 2004·Microsurgery·Edwin E QuanClaudio Maldonado
Mar 7, 2012·Cell Biochemistry and Function·Anjana Chandrasekhar, Amal Kanti Bera
May 20, 1999·Circulation·V J OwenS E Harding
Mar 27, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Qining QinJames M Downey
Oct 3, 2001·Physiological Reviews·L H SnoeckxG J Van Der Vusse
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Babar ChaudhriSian E Harding
Oct 1, 1996·Journal of Cardiovascular Pharmacology and Therapeutics·Y BirnbaumR A Kloner
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·E R SchwarzP Hanrath

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