Acceleration of genetic gain in cattle by reduction of generation interval

Scientific Reports
Poothappillai KasinathanMark F Allan

Abstract

Genomic selection (GS) approaches, in combination with reproductive technologies, are revolutionizing the design and implementation of breeding programs in livestock species, particularly in cattle. GS leverages genomic readouts to provide estimates of breeding value early in the life of animals. However, the capacity of these approaches for improving genetic gain in breeding programs is limited by generation interval, the average age of an animal when replacement progeny are born. Here, we present a cost-effective approach that combines GS with reproductive technologies to reduce generation interval by rapidly producing high genetic merit calves.

References

Dec 4, 2001·Nature Biotechnology·P KasinathanJ M Robl
Aug 3, 2006·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·L R Schaeffer
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Jan 1, 2013·Annual Review of Animal Biosciences·Theo MeuwissenMike Goddard

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Citations

Nov 12, 2016·Current Opinion in Biotechnology·Alison Louise Van Eenennaam
Mar 21, 2018·Animal : an International Journal of Animal Bioscience·D A Kenny, C J Byrne
Nov 21, 2017·Journal of Dairy Science·S G Moore, J F Hasler
Aug 10, 2017·Molecular Reproduction and Development·Louisa J ZakEgbert F Knol
Nov 26, 2019·Animal : an International Journal of Animal Bioscience·L B FerréP J Ross
Dec 6, 2018·Nature Reviews. Genetics·Michel GeorgesBen Hayes
Dec 15, 2018·Biology of Reproduction·Daniel E GoszczynskiPablo J Ross
Jul 20, 2019·Transgenic Research·Alison L Van Eenennaam
Nov 21, 2019·Tropical Animal Health and Production·Alejandro AmayaMario Cerón-Muñoz
Sep 27, 2018·Translational Animal Science·Maci L MuellerAlison L Van Eenennaam
Feb 13, 2021·Genes·Veena UnnikrishnanJacob Thundathil
Nov 12, 2020·Frontiers in Genetics·Chongyang Wu, Marc-André Sirard

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Methods Mentioned

BETA
genotyping
biopsy
FCS
Profiler

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