Acceleration of methaemoglobin reduction by riboflavin in human erythrocytes

British Journal of Haematology
T MatsukiY Tani


The effect of riboflavin on nitrite treated erythrocytes from normal subjects and patients with hereditary methaemoglobinaemia due to the deficiency of NADH-cytochrome b5 reductase was studied in the presence of glucose, 2-deoxy-D-glucose or lactate. When glucose or 2-deoxy-D-glucose was used as a substrate for these erythrocytes, the rate of methaemoglobin reduction in these cells was accelerated more than two-fold in the presence of riboflavin. The acceleration was dependent on the concentration of riboflavin and was suppressed by the addition of atebrin. The stimulative effect of riboflavin was, however, not observed when lactate was used in place of glucose or 2-deoxy-D-glucose. On the basis of these results, the acceleration of methaemoglobin reduction by riboflavin was considered to be due to the activation of NADPH-flavin reductase (Yubisui et al, 1977) in erythrocytes by the reagent. The availability of riboflavin for patients with methaemoglobinaemia due to the deficiency of NADH-cytochrome b5 reductase and for those with toxic methaemoglobinaemia is discussed in relation to methaemoglobin reducing systems in erythrocytes.


May 9, 1977·Biochemical and Biophysical Research Communications·T YubisuiY Yoneyama
Oct 1, 1976·The Journal of Clinical Investigation·E N MetzA L Sagone
Nov 1, 1974·European Journal of Biochemistry·M F SchmidtC Scholtissek
Oct 1, 1969·The Journal of Clinical Investigation·E Beutler
Sep 1, 1957·Archives of Biochemistry and Biophysics·H H ROSTORFER, M J CORMIER
Jan 22, 1971·Nature·D H PageK Winkler

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Jan 1, 1983·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M SuzukiN S Agar
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May 1, 1990·American Journal of Hematology·T YubisuiD E Hultquist
Dec 22, 2019·Antioxidants·Emmanuel AnkamahJohn M Nolan
Sep 1, 1981·Archives of Biochemistry and Biophysics·K S Blisard, J J Mieyal
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