Acceleration of papilloma growth in mice fed high-fat diets during promotion of two-stage skin carcinogenesis

Nutrition and Cancer
D F BirtL Schweickert

Abstract

The effect of feeding a high-fat diet during the promotion phase of skin tumorigenesis was assessed in SENCAR mice. Tumors were initiated on the backs of mice by application of 10 nmol 7,12-dimethylbenz[a]anthracene (DMBA); the tumors were then promoted beginning one week later with twice weekly treatments of 2 micrograms 12-O-tetradecanoylphorbol-13-acetate (TPA) each in 0.2 ml acetone. Control diet containing 5% corn oil was fed from four weeks before until one week after DMBA treatment in all groups. A high-fat diet (24.6% corn oil) was fed from one week after DMBA treatment; the other groups continued on the control diet. Mice were fed ad libitum, and those given the high-fat diet consumed more calories early in the study than the controls did. Treatment with TPA increased calorie consumption throughout the study. Body weights were elevated in mice fed high-fat diets and reduced by TPA treatment. The average number of papillomas per mouse did not differ between the low- and high-fat groups, but papillomas grew more rapidly on the mice fed a high-fat diet than those fed a low-fat diet. The feeding of a high-fat diet following DMBA treatment, in the absence of TPA administration, did not result in promotion of skin tumors. Th...Continue Reading

References

Dec 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·S Graham
Jan 1, 1986·Advances in Experimental Medicine and Biology·D F Birt
Jan 1, 1953·Advances in Cancer Research·A TANNENBAUM, H SILVERSTONE

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Citations

Oct 18, 2003·Metabolism: Clinical and Experimental·Elsa J BrochmannSamuel S Murray
Jan 1, 1991·Nutrition and Cancer·M LocniskarS M Fischer
Jul 29, 2011·Annals of the New York Academy of Sciences·Tricia MooreJohn DiGiovanni
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J R Hebert, D R Miller

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