PMID: 6537689Jan 1, 1984Paper

Acceleration of peritoneal solute transport by cytochalasin D

Uremia Investigation
P HirszelJ F Maher

Abstract

Because cytochalasin D affects intercellular junctions the effect of this agent on peritoneal transport was investigated in normal rabbits. Using commercially available dialysis solution, short-term control peritoneal dialyses were compared in the same animals to dialyses in which cytochalasin D was added intraperitoneally. A dose (325-920 micrograms/kg) dependent increase in peritoneal clearances of urea (49% increment at high dose) and of creatinine (67% increment) occurred when cytochalasin D was added. When solute transport was highest at the maximal dose, osmotically induced ultrafiltration decreased significantly to 33% of control values. Cytochalasin D induces aberrations in solute transport that resemble those accompanying and occasionally following peritonitis.

References

Oct 1, 1978·Experimental Cell Research·Y MiyakeY Okada
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·K NolphR Popovich
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·J F MaherD C Hohnadel
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J F GriffinC Y Jung
Dec 1, 1980·The Journal of Cell Biology·I MezaM Cereijido
Jan 1, 1982·The Journal of Cell Biology·M Schliwa
Nov 1, 1981·Kidney International·C B DunhamA M Mattocks
Feb 1, 1980·Toxicology and Applied Pharmacology·T TrirawatanapongT Anukarahanonta

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Citations

May 1, 1989·Kidney International·M D LevittM C Overdahl

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