PMID: 2507957Oct 1, 1989Paper

Acceleration of scrapie in neonatal Syrian hamsters

Neurology
M P McKinleyS B Prusiner

Abstract

Prions cause Creutzfeldt-Jakob disease, Gerstmann-Sträussler syndrome, and kuru of humans as well as scrapie of animals. Prolonged incubation periods, from months to decades, precede clinical disease. In studies on the biochemical characteristics of prions, weanling Syrian hamsters have been used extensively because they have relatively short incubation periods. In studies reported here, inoculation of neonatal hamsters significantly shortened the scrapie incubation period even further. Our results show that the scrapie incubation period in hamsters is a function of age. The interval between inoculation and death from scrapie plotted as a function of age (0 to 30 days) gave a correlation coefficient (r) of 0.86. The duration of clinical disease was also shortened in the hamsters inoculated as neonates compared with weanlings. Intraventricular injection of nerve growth factor prior to inoculation of neonates with scrapie significantly diminished the acceleration observed with scrapie alone in neonates. Histopathologic studies of brain from scrapie-inoculated neonates showed more extensive neuronal loss in the hippocampus and neocortex as well as a more profound gliosis in the caudate compared with animals inoculated as weanlings...Continue Reading

Citations

Jan 1, 1991·Annals of Neurology·C J EpsteinS B Prusiner
May 2, 2002·The European Journal of Neuroscience·Nicole SalèsKenneth L Moya
Sep 30, 2014·Acta Neuropathologica·Jacob I AyersDavid R Borchelt
Jun 6, 1994·Annals of the New York Academy of Sciences·N HunterJ Hope
Oct 11, 2005·Journal of Neuropathology and Experimental Neurology·Frank O Bastian
Jul 15, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Mustafa Al-ZoughoolDaniel Krewski
Aug 22, 1991·Nature·C Weissmann
Aug 29, 1996·Nature·R M AndersonG A Wells

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