Acceleration of second and fourth metatarsal fracture healing with recombinant human bone morphogenetic protein-2/calcium phosphate cement in horses

Veterinary Surgery : VS
Melanie PerrierMark Markel

Abstract

To compare the efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2)/calcium phosphate (CP) to autogenous cancellous bone graft (CBG) and to no treatment on bone healing, in surgically induced osteotomies and ostectomies of the accessory metatarsal bones in an equine model. Experimental. Adult horses (n=9). Segmental ostectomies of the second metatarsal bone (MT2) and osteotomies of the fourth metatarsal bone (MT4) were performed bilaterally in 9 horses. There were a total of 35 defects (1 MT4 was previously fractured) created and supplemented randomly either with no treatment (untreated control), rhBMP-2/CP cement, or matrix (CPC or CPM), or CBG. Radiography was performed every 2 weeks until study endpoint at 12 weeks. After euthanasia, bone healing was evaluated using radiography, mechanical testing, and histology. Data were analyzed with ANOVA followed by the Duncan's Multiple Range Test or nonparametric analyses. At 12 weeks, radiographic scores for union were significantly greater for the rhBMP-2 (P<.0001) and CBG (P=.004) groups compared with the untreated control group, for both MT2 ostectomies and MT4 osteotomies. The rhBMP-2 treated MT2 had greater maximum torque to failure in torsion than CBG and contro...Continue Reading

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Citations

Mar 1, 2012·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·J M CohenD M Nunamaker
Jul 19, 2012·Veterinary Surgery : VS·Laurie A McDuffeeElmabrok Masaoud
Sep 27, 2014·Veterinary Surgery : VS·Tiffany L SarrafianLarry D Galuppo
Jan 1, 2013·Journal of Functional Biomaterials·Sergey V Dorozhkin
Dec 28, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alyssa N BallLaurie R Goodrich
Oct 4, 2012·The Journal of Bone and Joint Surgery. American Volume·Howard J SeehermanJohn M Wozney
Jan 23, 2021·Animals : an Open Access Journal From MDPI·Iris RibitschFlorien Jenner

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