Acceleration of the biosynthesis of rat striatal dopamine by incubation and by administration of gamma-butyrolactone

Journal of Neuroscience Research
L E Dyck, C W Kazakoff


The concentration of dopamine in striatal slices obtained from rats treated with an MAO inhibitor was increased significantly by a 50-minute incubation in oxygenated Krebs buffer at 37 degrees C. Administration of alpha-methyl-p-tyrosine did not antagonize this small increase in dopamine. The extent of the incubation-induced increase was much greater in tissue obtained from control rats and was also greater than that resulting from the intraperitoneal administration of gamma-butyrolactone (GBL). Prior administration of alpha-methyl-p-tyrosine, d-amphetamine, apomorphine, or lergotrile significantly antagonized the increases in striatal dopamine levels induced by GBL administration or by incubation of striatal slices obtained from control rats. The prior administration of phenylethylamine, however, antagonized the incubation-induced, but not the GBL-induced, increase in striatal dopamine. In conclusion, the effect of incubating striatal slices on their dopamine levels was similar to that of administering GBL in that the incubation enhanced the activity of tyrosine hydroxylase that in turn produced an accelerated synthesis of dopamine.


Aug 1, 1979·European Journal of Pharmacology·C F Van ValkenburgA Wijling
Nov 2, 1979·Brain Research·M H WeilerD J Jenden
Dec 1, 1975·European Journal of Pharmacology·A Handforth, T L Sourkes
Feb 1, 1974·Journal of Neurochemistry·J M Saavedra
Aug 1, 1972·Biochemical Pharmacology·J R Walters, R H Roth
Jul 1, 1973·Canadian Journal of Biochemistry·D A DurdenA A Boulton
Oct 1, 1971·Journal of Neurochemistry·P F SpanoG L Gessa

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Jul 5, 1996·Neuroscience Letters·J J Feigenbaum, R Simantov
Nov 1, 1996·The International Journal of Neuroscience·J J Feigenbaum, S G Howard
Oct 29, 2003·Neurological Research·Christoph GreinerErwin-Josef Speckmann

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