Acceleration time of systolic coronary flow velocity to diagnose coronary stenosis in patients with microvascular dysfunction

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Kazushi TakemotoTakashi Akasaka

Abstract

The aim of this study was to test whether acceleration time of systolic coronary flow velocity could contribute to the diagnosis of coronary stenosis in patients with microvascular dysfunction, on the basis of the hypothesis that systolic coronary flow is less influenced by microvascular function because of compressed myocardium. Coronary flow velocity was assessed in the left anterior descending coronary artery during hyperemia with intravenous adenosine by echocardiography in 502 patients who were scheduled for coronary angiography because of coronary artery disease and significant valvular disease. Coronary flow velocity reserve (CFVR) and the percentage acceleration time (%AT), as the percentage of the time from the beginning to the peak of systolic coronary flow over systolic time during hyperemia, were calculated. The diagnostic ability of CFVR and %AT for angiographic coronary artery stenosis was then analyzed. As invasive substudies, fractional flow reserve and %AT by a dual-sensor (pressure and Doppler velocity) guidewire were measured simultaneously with %AT on transthoracic echocardiography (n = 14). Patients with coronary stenosis had significantly lower CFVR (1.7 ± 0.4) and greater %AT (65 ± 9%) compared with those...Continue Reading

References

Sep 1, 1976·Progress in Cardiovascular Diseases·F J Klocke
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Apr 15, 1987·The American Journal of Cardiology·D LevyW P Castelli
Feb 1, 1985·Journal of Biomechanical Engineering·J I HoffmanL M Messina
Jun 1, 1982·Circulation Research·W M Chilian, M L Marcus
Jan 1, 1994·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·T AkasakaS Miyake
Sep 1, 1993·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·J YoshikawaT Takagi
Sep 29, 1999·Lancet·K ShimadaJ Yoshikawa
May 12, 2001·The American Journal of Cardiology·S HigashiueJ Yoshikawa
Jan 31, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Kumiko HirataJunichi Yoshikawa
May 29, 2004·The American Journal of Cardiology·Kumiko HirataJunichi Yoshikawa
Apr 11, 2006·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Nurcan AratIrfan Sabah
Feb 23, 2007·The New England Journal of Medicine·Paolo G Camici, Filippo Crea
Oct 29, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Shinji InabaJitsuo Higaki
Mar 1, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Patrick MeimounJerome Clerc
Apr 26, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ana Djordjevic-DikicMiodrag Ostojic
Apr 29, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Johnny VegsundvågTorstein Hole
Oct 21, 2011·Congenital Heart Disease·Thais A L PedersenKristian Emmertsen
Jun 5, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Massimo RuscazioLuigi Meloni

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