PMID: 16528913Mar 15, 2006Paper

Accelerator mass spectrometry for quantitative in vivo tracing

BioTechniques
John S Vogel

Abstract

Accelerator mass spectrometry (AMS) counts individual rare, usually radio-, isotopes such as radiocarbon at high efficiency and specificity in milligram-sized samples. AMS traces very low chemical doses (micrograms) and radiative doses (100 Bq) of isotope-labeled compounds in animal models and directly in humans for pharmaceutical, nutritional, or toxicological research. Absorption, metabolism, distribution, binding, and elimination are all quantifiable with high precision after appropriate sample definition.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K W TurteltaubJ C Davis
Feb 1, 1995·Carcinogenesis·C E FrantzK W Turteltaub
May 12, 1997·Mutation Research·K W TurteltaubN Shen
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·R J MautheK W Turteltaub
Jun 25, 2002·The Journal of Biological Chemistry·Denis JossePatrick Masson
Oct 9, 2002·Current Drug Metabolism·Ian A Blair, Anita Tilve
Dec 19, 2002·Molecular & Cellular Proteomics : MCP·Katherine E WilliamsA L Burlingame
Jan 4, 2003·Analytical Chemistry·Marina L Chiarappa-ZuccaAdam H Love
Mar 4, 2003·Nature Reviews. Drug Discovery·Graham Lappin, R Colin Garner
Mar 14, 2003·Environmental Health Perspectives·John S VogelBruce A Buchholz
May 6, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·R D CombesP Wilcox
Jun 5, 2003·Journal of Lipid Research·Shawna L LemkeAndrew J Clifford
Sep 19, 2003·Analytical and Bioanalytical Chemistry·Stefan Stürup
Jan 15, 2004·Analytical Chemistry·Rosa G LibermanPaul L Skipper
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
Aug 24, 2004·The American Journal of Clinical Nutrition·Yumei LinAndrew J Clifford
Nov 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yawen LiMichael J Cima
Dec 8, 2004·Archives of Biochemistry and Biophysics·W W Cleland
Jan 22, 2005·Science·Tom P GuildersonTom A Brown
Mar 15, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Man Ho ChoiSteven R Tannenbaum
Jan 13, 2006·Methods in Enzymology·John S Vogel, Adam H Love
Nov 4, 1977·Science·D E NelsonW R Stott

❮ Previous
Next ❯

Citations

Mar 9, 2012·Advances in Urology·James S ChangChong-Xian Pan
Jun 19, 2009·Journal of Biomedical Science·Sang Soo HahKenneth W Turteltaub
Jun 17, 2008·Mass Spectrometry Reviews·Sam Matteson
May 12, 2009·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Sang Soo Hah
Nov 5, 2010·Advanced Drug Delivery Reviews·Stephen R DuekerJohn S Vogel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.