Acceptability, adherence and economic analyses of a new clinical pathway for the identification of non-responders to glaucoma eye drops: a prospective observational study.

The British Journal of Ophthalmology
Heather WatermanPippa Anderson

Abstract

Assess whether a new clinical pathway for glaucoma was acceptable to patients and healthcare professionals and whether it provided useful clinical information on non-responsiveness and non-adherence to the treatment of elevated intraocular pressure with latanoprost eye drops. A single arm non-randomised prospective observational study incorporating new glaucoma/ocular hypertension patients. To assess issues of acceptability, qualitative observation and interviews were conducted with patients and healthcare professionals. To determine clinical responsiveness, intraocular pressures were measured before and 4 hours after a clinician-instilled eye drop over two distinct appointments. Adherence data were collected using a Medicine Event Monitoring System. Economic analyses compared the costs between novel and standard care pathways. Of 72 patients approached, 53 entered the study (74.3%) and 50 completed all procedures (94.3%). Intraocular pressure was reduced more than 15% in 83 out of 92 study eyes by final visit (90.2%). The non-response rate was 5.1% once the effect of low adherence was minimised. For the 1376 drop instillation days under observation, eye drops were instilled as prescribed on 1004 days (73.0%), over-instilled on...Continue Reading

References

Jun 17, 2006·Journal of Glaucoma·Luca RossettiNicola Orzalesi
Jan 19, 2008·Journal of Behavioral Medicine·Karen S Ingersoll, Jessye Cohen
Jul 20, 2010·BMC Medical Research Methodology·Mubashir ArainGillian A Lancaster
Jun 13, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Colin Cook, Paul Foster
Apr 29, 2015·Ophthalmology·Paula Anne Newman-CaseyPaul P Lee

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