Acceptability and Feasibility of Real-Time Antiretroviral Therapy Adherence Interventions in Rural Uganda: Mixed-Method Pilot Randomized Controlled Trial

JMIR MHealth and UHealth
Angella MusiimentaJessica E Haberer

Abstract

Wireless electronic adherence monitors can detect antiretroviral therapy (ART) adherence lapses and trigger interventions in real time, thus potentially avoiding unnecessary HIV viremia. Evidence about the acceptability and feasibility of these monitors and associated interventions, however, is limited. The aim of this study was to assess the acceptability and feasibility of real-time adherence monitoring linked to text messaging (short message service, SMS) reminders and notifications to support adherence among individuals living with HIV who are taking ART in rural southwestern Uganda. Individuals living with HIV who were initiating ART were enrolled in a pilot randomized controlled trial and followed up for 9 months. Participants received a real-time adherence monitor and were randomized to one of the following study arms: (1) scheduled SMS, (2) SMS triggered by missed or delayed doses, or (3) no SMS. SMS notifications were also sent to 45 patient-identified social supporters for sustained adherence lapses in the scheduled SMS and triggered SMS arms. Study participants and social supporters participated in qualitative semistructured in-depth interviews on acceptability and feasibility of this technology. An inductive, conten...Continue Reading

Associated Clinical Trials

Oct 8, 2013·Jessica Haberer, MD, Jessica Haberer, MD

References

Oct 6, 2005·Qualitative Health Research·Hsiu-Fang Hsieh, Sarah E Shannon
Sep 3, 2010·AIDS and Behavior·Jessica E HabererDavid R Bangsberg
Jun 30, 2012·BMJ : British Medical Journal·Edward J MillsNathan Ford
Jul 14, 2012·Psychology, Health & Medicine·M H M M T van VelthovenJ Car
Aug 21, 2013·AIDS Research and Treatment·Mary Bachman DesilvaLora Sabin
Nov 28, 2013·Journal of the International AIDS Society·Ingrid T KatzAlexander C Tsai
Apr 19, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lora L SabinAllen L Gifford
Sep 12, 2015·Journal of General Internal Medicine·Jeffrey I CampbellJessica E Haberer

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Citations

Mar 10, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeremy D YoungJaveed Siddiqui
Jun 23, 2020·JMIR MHealth and UHealth·Stephen B Lee, Joanne Valerius
May 12, 2020·Current HIV/AIDS Reports·Rindcy DavisRebecca Schnall
Aug 18, 2021·Internet Interventions : the Application of Information Technology in Mental and Behavioural Health·Wilson Tumuhimbise, Angella Musiimenta

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Clinical Trials Mentioned

NCT01957865

Software Mentioned

UTAUT
NVIVO
STATA

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