Acceptability and Validity of the EQ-5D in Patients Living With Dementia

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Bernhard MichalowskyWolfgang Hoffmann

Abstract

To assess the acceptability and validity of the 3 levels of the EQ-5D (EQ-5D-3L) compared with the Quality of Life in Alzheimer's Diseases (QoL-AD) in patients living with dementia. The analysis was based on 560 dyads of persons with dementia and their caregivers of the multicenter observational study of dementia care networks in Germany (DemNet-D). Health-related quality of life was assessed by face-to-face interviews using the EQ-5D-3L (self-rating) and the QoL-AD (self- and proxy-rating). The number of missing values, the score ranges (observed vs possible range) and the floor and ceiling effects were used to assess the acceptability. We used one-way analyses of variance and multivariate linear regression models to evaluate the discriminative ability. The convergent validity was assessed using Spearman's correlation coefficient (rs) and multivariate regression models. The EQ-5D index had a higher response rate (89% vs 84%) and a comparable floor (>1%) but a higher ceiling effect (18% vs >1%) compared with the QoL-AD. Both measures can significantly differentiate between different stages of general health, instrumental activities of daily living, and depression. The EQ-5D index and the visual analog scale self-rating scores s...Continue Reading

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Citations

Mar 25, 2021·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Richard Huan XuShuyang Zhang
Apr 4, 2021·Brain Sciences·Tara PeseschkianOlivia Schreiber-Katz
Oct 7, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ole MartenWolfgang Greiner

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