Acceptability of Liquid Human Growth Hormone (hGH) [Norditropin Simple Xx®] in Adults and Children with GH Deficiency and Children with Chronic Renal Disease

Clinical Drug Investigation
M L DrentJ M Wit

Abstract

Human growth hormone (GH) is well established as a treatment for growth hormone deficiency. Recently, a new liquid GH formulation (Norditropin SimpleXx®) has become available that does not require reconstitution before subcutaneous self-administration with a new delivery system (NordiPen™) and an optional auto-injector (NordiPenmate™). In this study the acceptability and tolerability of and compliance with the liquid formulation were investigated DESIGN AND PATIENTS: An open 6-week multicentre trial in 53 patients, including adults and children, was performed in The Netherlands. Acceptability and tolerability of the liquid GH formulation were assessed by questionnaires and compliance by both questionnaires and re-collection of GH cartridges MAIN OUTCOME MEASURES AND RESULTS: The mean daily dosage of GH was 0.24 mg/m2(0.03 to 0.82 mg/m2) in adults and 1.13 mg/m2(0.65 to 1.77 mg/m2) in children. Most patients (91% of adults and 89% of children) preferred to continue on the new GH formulation rather than the previously used formulation. This was mainly due to the easier and less time-consuming procedure and the good tolerance of the drug. Self-reported compliance also improved, but this could not be proven due to poor return of st...Continue Reading

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Citations

Sep 30, 2009·Nature Reviews. Nephrology·Kai-Uwe Eckardt, Bertram L Kasiske
Aug 8, 2019·The Journal of Dermatology·Hyoseung ShinHyunsun Park
Feb 14, 2020·PloS One·Muhammed HassenMogamat Razeen Davids
Nov 30, 2006·Annals of the Royal College of Surgeons of England·Ying-Ying SeowPhilip Dyer
Nov 13, 2004·Hormone Research·Anne-Marie KappelgaardTorben Laursen
May 15, 2013·Expert Opinion on Biological Therapy·Anna Pawlikowska-Haddal
Feb 8, 2011·Journal for Specialists in Pediatric Nursing : JSPN·Monali BhosleWon Chan Lee

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