Acceptance of genetic testing for hereditary breast ovarian cancer among study enrollees from an African American kindred

American Journal of Medical Genetics. Part a
A Y KinneyKen R Smith

Abstract

Clinical availability of genetic testing for cancer predisposition genes is generating a major challenge for U.S. health care systems to provide relevant genetic services to underserved populations. Here we present rates of study enrollment and utilization of genetic testing in a research study on BRCA1 testing acceptance in one large kindred. We also present data on baseline access to genetic information as well as enabling and obstructing factors to study enrollment. The study population included female and male members of an African American kindred based in the rural southern United States with an identified BRCA1 mutation. A combination of quantitative and qualitative data were collected and analyzed. Of the 161 living, eligible, and locatable kindred members, 105 (65%) enrolled in the study. Family, personal, and educational motivations were the most commonly endorsed reasons for study participation. The most commonly cited reasons for refusal to participate in the study were: lack of interest, time constraints, and negative experiences with prior participation in genetic research. Eighty three percent of the participants underwent BRCA1 testing. In multiple logistic regression analysis, age 40-49 (odds ratio (OR) = 6.9; ...Continue Reading

References

Jan 1, 1991·Social Science & Medicine·C D Sherbourne, A L Stewart
Jul 3, 1996·Journal of the National Cancer Institute·J R BotkinJ E Nash
Jun 1, 1997·American Journal of Public Health·W J StrawbridgeG A Kaplan
Nov 14, 1997·Patient Education and Counseling·C HughesC Lerman
Dec 5, 1998·Journal of the National Cancer Institute·E B ClausG Parmigiani
Sep 10, 1999·Preventive Medicine·M StefanekC Lerman
Apr 3, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·C M Velicer, S Taplin
Apr 17, 2001·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·W J StrawbridgeG A Kaplan
Jan 22, 2002·Current Opinion in Obstetrics & Gynecology·Steven A Narod, Jeff Boyd
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas S FrankGregory C Critchfield
Jun 12, 2002·Oncology Nursing Forum·Anita Yeomans KinneyRobert T Croyle
Nov 20, 2002·Archives of Internal Medicine·Giselle Corbie-SmithDiane Marie M St George
Dec 20, 2002·Cancer·Olufunmilayo I OlopadeCarolyn Whitfield-Broome
Mar 26, 2003·American Journal of Medical Genetics. Part a·Bonnie Jeanne BatySara Marie Ellis
Apr 4, 2003·American Journal of Medical Genetics. Part a·Jeffrey R BotkinElaine Lyon
Oct 24, 2003·Patient Education and Counseling·Chanita HughesClinton Finch
Oct 25, 2003·Science·Mary-Claire KingUNKNOWN New York Breast Cancer Study Group
May 14, 2004·Genetic Testing·Eleanor SingerJohn Van Hoewyk
Apr 14, 2005·JAMA : the Journal of the American Medical Association·Katrina ArmstrongMary Putt
Apr 19, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Lisa KesslerChanita Hughes Halbert
Aug 17, 2005·Cancer Investigation·Chanita Hughes HalbertEdith Mitchell
Sep 1, 1971·Journal of Motor Behavior·C D Spielberger

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Citations

Jan 12, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Anita Yeomans KinneyMaritza Arce-Laretta
Nov 8, 2014·Journal of the National Cancer Institute·Anita Y KinneyRebecca A Campo
Jan 27, 2009·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Anita Y KinneyJoseph B Fanning
Apr 2, 2010·American Journal of Medical Genetics. Part a·Jennifer Permuth-WeyTuya Pal
Nov 4, 2006·Social Science & Medicine·Lee EllingtonAnita Y Kinney
Oct 11, 2014·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Inez AdamsVanessa B Sheppard
Apr 28, 2016·American Journal of Preventive Medicine·Tarsha JonesMaria C Katapodi
Jun 22, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anita Y KinneyMarc D Schwartz
Apr 3, 2014·Qualitative Health Research·Alicia Navarro de SouzaNora Wong
Jul 13, 2016·Journal of Genetic Counseling·Alejandra Hurtado-de-MendozaVanessa B Sheppard
Oct 28, 2006·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Bonnie J BatyAnita Y Kinney
Dec 14, 2007·American Journal of Medical Genetics. Part a·Chanita Hughes HalbertSusan Domchek
Sep 26, 2019·Journal of Genetic Counseling·Colin M E HalversonGeorgia L Wiesner
Mar 7, 2014·The American Journal of Bioethics : AJOB·Ellen Wright ClaytonUNKNOWN Clinical Sequencing Exploratory Research (CSER) Consortium Pediatrics Working Group
Dec 5, 2019·International Journal of Environmental Research and Public Health·Alejandra Hurtado-de-MendozaVanessa B Sheppard

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