Acceptance of skin grafts between mice bearing different allelic forms of beta 2-microglobulin

Transplantation
R A HedererP J Robinson

Abstract

Single amino acid disparities in MHC class I molecules can elicit transplantation responses. Since beta 2 microglobulin (beta 2m) is noncovalently associated with class I antigens on the cell membrane we investigated whether the single amino acid polymorphism at position 85 (Asp-->Ala) in the mouse beta 2m molecule can cause skin graft rejection. A B2mb transgene was introduced into CBA(B2ma) mice which subsequently expressed both forms of beta 2m. Skin from these CBA beta 2mb transgenic mice was not rejected by the parental CBA strain. Previous studies showed that cytotoxic T lymphocyte (CTL) responses directed against beta 2mb use H2Kb as a restriction element. We therefore produced mice expressing H2Kb and H2Ab as well as beta 2mb by crossing CBA.beta 2mb mice with either CBA.Kb (CBK) transgenic mice or C3H.SW mice and used these as skin graft donors for beta 2mb negative littermates. In both cases rejection of transgenic skin only occurred when mice had received both a beta 2mb graft and an H2-disparate allograft lying adjacent in the same site. Introduction of the male specific antigen, H-Y, as a helper determinant did not result in rejection of beta 2mb skin. Neither did two CTL determinants (P91A and beta 2mb) on the sam...Continue Reading

References

Jul 1, 1976·European Journal of Immunology·E SimpsonP Chandler
Nov 1, 1975·The Journal of Experimental Medicine·R D GordonL E Samelson
Aug 23, 1990·Nature·B PérarnauF A Lemonnier
Jan 1, 1991·Immunogenetics·R J GraffD C Roopenian
Jan 1, 1990·Immunogenetics·A P Davis, D C Roopenian
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D E SpeiserR M Zinkernagel
May 1, 1986·Transplantation·S Cobbold, H Waldmann
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E De PlaenT Boon
Jan 1, 1984·Immunogenetics·P J RobinsonK F Lindahl
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P J RobinsonK Sege
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·F T GatesT J Kindt
Jul 1, 1982·Molecular Immunology·L GrafP J Robinson
May 1, 1981·The Journal of Experimental Medicine·B E LovelandI F McKenzie
Jan 1, 1982·Immunogenetics·R W MelvoldG R Dunn
Jan 1, 1993·Immunogenetics·K F Lindahl
May 1, 1964·Transplantation·D G GILMOUR

❮ Previous
Next ❯

Citations

Nov 22, 1997·Current Opinion in Immunology·E Simpson, D Roopenian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.