Access to Isothiazolones from Simple Acrylamides by Pd-Catalyzed C-H Bond Activation

The Journal of Organic Chemistry
Mu-Yi ChenTatiana Besset

Abstract

A new methodology was developed to access isothiazolone derivatives from simple acrylamides by transition metal catalyzed C-H bond functionalization. This Pd-catalyzed reaction using an electrophilic SCN source offered an efficient tool to access a panel of functionalized isothiazolone derivatives (21 examples, up to 71% yield).

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Citations

Aug 25, 2020·Chemistry : a European Journal·Mélissa GaoTatiana Besset
Feb 3, 2021·Organic & Biomolecular Chemistry·Nallappan SundaraveluGovindasamy Sekar
Jun 4, 2021·Chemical Communications : Chem Comm·Louise RuyetTatiana Besset
Sep 18, 2020·Organic Letters·Mu-Yi ChenTatiana Besset
Sep 28, 2021·The Journal of Organic Chemistry·Majji ShankarAkhila K Sahoo

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